| STC1在胃癌组织与外周血液中表达的意义 |
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| 引用本文： | 唐小龙,江振友,蔡淑玉,许礼发,周昕. STC1在胃癌组织与外周血液中表达的意义[J]. 中国病理生理杂志, 2008, 24(5): 978-981. DOI: 1000-4718 |
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| 作者姓名： | 唐小龙 江振友 蔡淑玉 许礼发 周昕 |
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| 作者单位： | 暨南大学医学院 1血液病研究所， 3微生物学与免疫学教研室， 广东 广州 510632； 2安徽理工大学医学院生物医学工程研究所,安徽 淮南 232001 |
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| 摘 要： | 目的：研究外周血液与胃癌组织中斯钙素1 (STC1)的表达情况。方法: 分别在I-IV型的胃癌74例患者中，应用RT-PCR法检测外周血和肿瘤组织中STC1 mRNA表达情况，应用免疫组化法检测肿瘤组织中STC1蛋白表达情况。结果: 74例胃癌患者，48例外周血液中STC1 mRNA阳性；肿瘤组织STC1 mRNA与STC1蛋白全部表达。外周血中STC1 mRNA与肿瘤淋巴结转移数、肿瘤大小和病理TNM分期有(r分别为0.637、0.519、0.541, P<0.05、P<0.01、P<0.05)显著正相关。结论: STC1在胃癌的发生发展过程中具有抑制免疫系统功能等重要作用；外周血中STC1 mRNA检测可试用作为肿瘤微转移的1个新指标。
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| 关 键 词： | 斯钙素1 肿瘤转移 |
| 文章编号： | 1000-4718(2008)05-0978-04 |
| 收稿时间： | 2006-09-26 |
| 修稿时间： | 2006-09-26 |
Significance of STC1 expression in peripheral blood and tissue of gastric carcinoma |
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| TANG Xiao-long,JANG Zhen-you,CAI Shu-yu,XU Li-fa,ZHOU Xin. Significance of STC1 expression in peripheral blood and tissue of gastric carcinoma[J]. Chinese Journal of Pathophysiology, 2008, 24(5): 978-981. DOI: 1000-4718 |
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| Authors: | TANG Xiao-long JANG Zhen-you CAI Shu-yu XU Li-fa ZHOU Xin |
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| Affiliation: | 1Institute of Hematology, 3Department of Microbiology and Immunology, Medical College, Jinan University, Guangzhou 510632, China; 2 Research Section of Biomedical Engineering, Medical College, Anhui University of Science and Technology, Huainan 232001, China. E-mail:tx19121033@tom.com |
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| Abstract: | AIM: To investigate stanniocalcin 1 (STC1) mRNA expression in the blood and tissue of gastric carcinoma. METHODS: The samples of peripheral blood and tumor tissues were collected from 74 patients with stage I-IV gastric carcinoma. STC1 mRNA was detected by RT-PCR, STC1 protein in tumor tissue was also detected by immunohistochemical method. RESULTS: The expression of STC1 mRNA in blood was significantly correlated with multiple histopathological prognostic factors, including primary tumor size, number of positive lymph nodes, and TNM stage. STC1 mRNA was not detected in the blood of volunteers without cancer, but detected in all gastric carcinoma tissue, and STC1 protein was expressed in all gastric carcinomas. CONCLUSION: STC1 is proposed as a novel, specific, and clinically useful molecular marker for detecting occult gastric carcinoma cells in blood. STC1 expression may play an important role in the progression of gastric carcinoma. |
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| Keywords: | Stanniocalcin 1 Neoplasms metastasis Stomath neoplasms |
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