厄贝沙坦联合美托洛尔治疗心力衰竭疗效分析及对血清脑钠肽水平的影响

目的 探讨厄贝沙坦联合美托洛尔治疗心力衰竭的疗效及对血清脑钠肽(BNP)水平的影响.方法 选取慢性充血性心力衰竭患者187例,随机分为观察组94例,对照组93例.对照组给予强心、利尿治疗.治疗组此基础上加用厄贝沙坦、美托洛尔.治疗前后检测BNP含量.结果 治疗后观察组总有效率高于对照组(P＜0.05).治疗后,观察组与对照组BNP均较治疗前显著降低(均P＜0.05).治疗前后BNP减少值观察组高于对照组(P＜0.05).结论 CHF患者在常规治疗基础上,联合应用厄贝沙坦及美托洛尔,能有效提高疗效,降低血清BNP水平,显著改善心功能.

Analysis of treatment effects and BNP detection in heart failure patients by Irbesartan and Metoprolol

Objective To investigate the irbesartan combined with metoprolol in the treatment of congestive heart failure and effects on serum Brainnatriuretic peptide. Methods 187 patients with chronic congestive heart fail- ure （CHF）,were randomly divided into the observation group 94 cases, 93 cases of the control group. The control group was given the strong heart, diuresis therapy. The treatment group on the basis of combined with irbesartan, meto- prolol. The content of BNP was detected before and after treatment. Results After treatment, the observation group to- tal efficiency is higher than that of the control group, the difference was statistically significant（ P 〈 0.05 ）. After treat- ment, the observation group and the control group of BNP were significantly lower, the difference was statistically sig- nificant（P 〈0.05 ）. Before and after treatment with BNP reduced value comparison between groups, the observation group than in the control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The patients with CHF on the basis of routine treatment, combined with irbcsartan and metoprolol, can effectively improve the curative effect, decrease the serum level of BNP,improve heart function.