糖化血红蛋白和N末端脑钠肽原与急性冠脉综合征患者心功能的相关性研究

目的 探讨糖化血红蛋白(HbAlc)和N末端脑钠肽原(NT-proBNP)与急性冠脉综合征(ACS)患者心功能的相关性.方法 选择53例ACS合并2型糖尿病(T2DM)(T2DM组)和67例ACS(ACS组)作为研究对象,采用免疫比浊法检测HbAlc水平,电化学发光法测定NT-proBNP含量并比较.结果 T2DM组HbAlc、NT-proBNP分别为(9.21±1.23)％、(3.56±1.12)ng/ml,均高于ACS组的(5.09±0.67)％、(0.14±0.04)ng/ml(t=6.495、9.277,均P＜0.01);ACS患者心功能与HbAlc、NT-proBNP呈正相关性(r=0.517、0.589,均P＜0.01),ACS患者HbAlc与NT-proBNP之间也呈正相关性(r=0.431,P＜0.05).结论 HbAlc和NT-proBNP对ACS患者心功能损伤有促进作者,可作为ACS心功能受损的诊断指标.

Study on the correlation between the levels of HbA1 c, plasma NT-proBNP and the cardiac function in patient with acute coronary syndrome

Objective To investigate the correlation between glycosylated hemoglobin（ HhAl c）, plasma NT- proBNP and the cardiac function in patients with acute coronary syndrome （ACS）. Methods 53 patients with both ACS and type 2 diabetes mellitus （T2DM） （T2DM group） ,67 patients with ACS（ ACS group） were selected as the objects. The HbAlc level was detected by immunohistochemical than turbidimetry, and the content of NT-proBNP was detected by electrochemiluminescence method. Results The levels of HbAlc ,plasma NT-proBNP of the T2DM group were（9.21 ± 1.23 ）%, （3.56 ± 1. 12 ）ng/ml, respectively, which were higher than those of ACS group （5.09 ± 0. 67 ） %, （0.14±0.04） ng/ml ] （ t = 6.495,9.277, all P 〈 0.01 ） ; The cardiac function of ACS patients was positive- ly correlated with the levels of HbA1 c and plasma NT-proBNP（ r = 0.517,0.589, all P 〈 0.01 ）, and there was posi- tive correlation between the levels of HbAlc and plasma NT-proBNP in ACS patients （ r = 0. 431, P 〈 0. 05 ）. Conclusion The HbAlc and NT-proBNP can promote the injury of the cardiac function of ACS patients, and can he used as diagnostic indicators of the injury of the cardiac function of ACS patients.