热毒宁、布地奈德、红霉素序贯疗法治疗小儿支原体肺炎的疗效及其作用机制

目的 观察热毒宁、布地奈德、红霉素序贯疗法治疗小儿支原体肺炎的临床疗效,并探讨其作用机制.方法 将78例小儿支原体肺炎按随机分为两组,每组39例.对照组雾化吸入布地奈德及红霉素序贯疗法联合治疗,观察组在对照组的基础上加用热毒宁.两组均治疗2周.观察两组临床疗效,并于治疗前后检测肺功能.结果 观察组总有效率为94.87％,明显高于对照组的86.62％(x2=6.683,P＜0.05);观察组退热、咳嗽改善、肺部哕音消失、哮鸣音消失、住院时间均明显短于对照组(均P＜0.01);观察组治疗后用力肺活量,第1秒用力呼气容积及最大呼气流速较对照组治疗后明显升高(均P＜0.05).结论 布地奈德、红霉素联合治疗的基础上,增加热毒宁注射液能提高临床治疗效果,缩短症状及体征改善时间,改善肺功能,可能与调节体液免疫能力及降低炎性细胞因子水平有关.

The efficacy and mechanism of combined treatment of Reduning, budesonide and erythromycin sequential therapy in the treatment of children with mycoplasma pneumonia

Objective To observe the efficacy of the combined treatment of Reduning,budesonide and eryth- romycin sequential therapy in the treatment of children with mycoplasma pneumonia and investigate its mechanism. Methods 78 children with mycoplasma pneumonia were randomly divided into two groups, each group 39 cases. The control group were given budesonide and erythromycin sequential therapy, and the observation group were given Re- duning injection on the basis of the control group. Both groups, were treated for 2 weeks. The clinical efficacy was ob- served, and before and after treatment,the pulmonary function was tested in the both groups. Results The total effec- tive rate of the observation group was 94.87%, which was higher than that of the control group （86.62%） （x2 = 6. 683, P 〈 0.05 ） ; The fever, cough improved, pulmonary rales disappeared, wheeze disappeared and hospital stay time of the observation group were significantly shorter than the control group（ all P 〈 0.01 ） ; The FVC, FEV1 and PEF of the observation group were higher than those of the control group （ all P 〈 0.05 ）. Conclusion On the basis of the combined treatment of budesonide and erythromycin, the addition of Reduning injection can improve clinical effect and shorten the symptoms and signs improve time,improve lung function, chich may in association with regulating humoral immunity and reducing the levels of inflammatory cytokines.