AP-1在胰腺癌组织中的表达

目的 探讨AP-1在胰腺癌组织中的表达情况及意义.方法 选取35例胰腺癌患者术后肿瘤组织石蜡包埋标本(观察组)及35例健康人胰腺组织(对照组),采用双抗体夹心ABC-ELISA法进行AP-1检测,观察两组标本C-JUN和C-FOS表达情况并进行比较.结果 C-JUN和C-FOS表达阳性率观察组分别为80.00％、71.43％,对照组分别为22.86％、28.57％,两组差异均有统计学意义(x2=22.88、12.86,均P＜0.05).结论 AP-1在胰腺癌组织中高度表达,可指导临床采取合理的干预措施减缓肿瘤发展.

The expression of AP-1 in pancreatic tumor cells

Objective To investigate the expression of AP-1 in pancreatic tumor cells and its clinical signifi- cance. Methods Selected the paraffin-embedded specimens from the tnmor tissues of 35 patients with pancreatic cancer（ study group） and 35 pancreatic tissue of healthy people（ control group）, and double antibody sandwich ABC- ELISA detection of AP-1 was carried out, two sets of specimens C-JUN and C-FOS expression was observed. Results Observation group C-JUN and C-FOS expression positive rates were 80.00% 71.43%, control group, C-JUN and C-FOS expression positive rates were 22.86% ,28.57% ,there was a significant difference between the two groups. Conclusion AP-1 was highly expressed in pancreatic cancer,which could guide clinical take reasonable in- terventions to slow tumor development.