硝苯地平控释片与缓释片治疗高血压疗效比较

目的 探讨硝苯地平缓释剂(SR)与硝苯地平控释剂(GITS)治疗原发性高血压的临床疗效.方法 将160例原发性高血压2级患者随机分为SR组和GITS组.SR组给予硝苯地平缓释片20 mg,2次/d;GITS组给予硝苯地平控释片30 ng,1次/d.两组均治疗8周,并对所有患者进行动态血压监测(ABPM),观察治疗前后两组患者的24 h平均血压、心率、谷/峰(T/P)值的变化及不良反应等情况.结果 治疗后GITS组收缩压(SBP)、舒张压(DBP)的T/P比值分别为68.5％、74.6％,均高于SR组的57.2％、61.1％(x2=6.32、7.05,均P＜0.05);GITS组心率低于SR组(t=4.17,P＜0.05);两组不良反应差异无统计学意义(x2=0.16,P＞0.05).结论 SR与GITS均能有效降压,但GITS更高效、平稳、安全,对心率的影响小.

Comparison of the effect of nifedipine controlled-release tablet and nifedipine sustained-release tablet in the treatment of hypertension

Objective To investigate the clinical efficacy of nifedipine sustained-release formulation （SR） and nifedipine controlled-release（GITS） in the treatment of essential hypertension. Methods 160 patients with es- sential hypertension were randomly divided into two groups. The SR group was treated with SR 20 mg twice a day; GITS group was treated with GITS 30 mg once a day. All patients were given ambulatory blood pressure monitoring （ABPM） and observed the 24-hour average blood pressure, heart rate, changes in the trough/peak （T/P） values, and adverse reactions before and after treatment in two groups. Results The T/P value of systolic blood pressure（SBP） and diastolic（DBP） in the GITS group was 68.5% ,74.6% , respectively, which were higher than those of SR group （57. 2% ,61.1% ） （ X2 = 6.32,7.05, all P 〈 0.05 ） ;GITS group was significantly lower than the SR group in heart rate （t = 4.17, P 〈 0.05 ） ;Adverse reactions between two groups had no significant difference （X2 = 0.16, P 〉 0.05 ）. Conclnsion SR and GITS can effectively lower blood pressure, but GITS is more efficient, stable, safe, small impact on the heart rate.