| 原发性肝癌患者血清IL-18及IL-18BP水平的测定及临床意义 |
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| 引用本文： | 廖湘晖,官成浓,姚伟红,蔡良真,卓文敏,冯冰,徐军发.原发性肝癌患者血清IL-18及IL-18BP水平的测定及临床意义[J].医学研究杂志,2008,37(12):47-48. |
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| 作者姓名： | 廖湘晖 官成浓 姚伟红 蔡良真 卓文敏 冯冰 徐军发 |
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| 作者单位： | 广东医学院附属医院肿瘤中心,湛江,524001 |
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| 基金项目： | 广东省湛江市科技计划
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| 摘 要： | 目的 探讨血清IL-18、IL-18BP的水平与原发性肝癌发生、发展的关系.方法 应用ELISA法检测28例原发性肝癌患者、21例肝硬化患者及18例正常人血清IL-18及IL-18BP的含量.比较它们之间的关系.结果 原发性肝癌患者血清IL-18水平明显低于正常人和肝硬化患者,IL-18BP的水平明显高于正常人和肝硬化患者(P<0.05);肝硬化患者血清IL-18及IL-18BP水平均明显高于正常人(P<0.01).结论 外周血IL-18及IL-18BP水平可作为反映原发性肝癌患者及肝硬化患者的免疫功能状态指标,也可以作为原发性肝癌的诊断指标.
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| 关 键 词： | 原发性肝癌 肝硬化 白细胞介素18 白细胞介素18结合蛋白 |
Clinical Significance of Serum IL-18 and IL-18BP in Patients with Primary Liver Cancer |
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| Liao Xianghui,Guan Chengnong,Cai Liangzhen,et al..Clinical Significance of Serum IL-18 and IL-18BP in Patients with Primary Liver Cancer[J].Journal of Medical Research,2008,37(12):47-48. |
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| Authors: | Liao Xianghui Guan Chengnong Cai Liangzhen |
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| Institution: | Liao Xianghui,Guan Chengnong,Cai Liangzhen,et al.The Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China |
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| Abstract: | Objective To study the relationships between serum IL-18 and IL-18BP and the development,metastasis,curative effect and prognosis of primary liver cancer.Methods There were total 49 cases patients,of which 28 cases primary hepaticcarcinoma(PHC)and 21 cases liver cirrhosis(LC),and 18 cases heathy people.Their serum levels of IL-18 and IL-18BP were determined by using an ELISA assay and comparation.Results The serum IL-18 in PHC was significantly lower than that in LC and controls;the serum IL-18BP in PHC was... |
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| Keywords: | Primary hepatic carcinoma(PHC) Liver cirrhosis(LC) Serum interleukin 18(sIL-18) Serum interleukin 18 link albumen(sIL-18BP) |
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