| 微小RNA在心血管领域的研究进展 |
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| 引用本文： | 恽佶例,李玉明.微小RNA在心血管领域的研究进展[J].心血管病学进展,2008,29(Z1). |
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| 作者姓名： | 恽佶例 李玉明 |
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| 作者单位： | 1. 天津医科大学,天津,300070;中国人民武装警察部队医学院附属医院,心血管病研究所,天津,300162
2. 中国人民武装警察部队医学院附属医院,心血管病研究所,天津,300162 |
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| 摘 要： | 微小RNA是一种参与生长发育、器官形成、造血、细胞增殖与凋亡、肿瘤生成等多种生物学过程的重要调控因子,其作用机制主要是与靶信使RNA(mRNA)结合,进而抑制mRNA编码蛋白质的翻译或直接进行mRNA的切割.最近的一些研究发现,miRNAs不但参与了骨骼肌和心肌生长发育的调控,而且还参与了心脏的机械重构和电重构过程,并在调节血管内皮功能方面亦发挥着重要作用.以上发现使微小RNA有可能成为心血管界的一个新的治疗靶目标.
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| 关 键 词： | 微小RNA 基因表达 心脏重构 心血管 研究进展 Fields Cardiovascular MicroRNAs Progress 靶目标 治疗 管界 血管内皮功能 调节 重构过程 机械重构 心脏 调控 心肌 骨骼肌 miRNAs 发现 切割 |
Research Progress of MicroRNAs in Cardiovascular Fields |
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| YUN Ji-li,LI Yu-ming.Research Progress of MicroRNAs in Cardiovascular Fields[J].Advances in Cardiovascular Diseases,2008,29(Z1). |
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| Authors: | YUN Ji-li LI Yu-ming |
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| Institution: | YUN Ji-li~(1,2),LI Yu-ming2 (1.Tianjin Medical University,Tianjin 300070,China,2.Institute of Cardiovascular Disease,The Affiliated Hospital of Medical College of Chinese People\' s Armed Police Forces,Tianjin 300162,China) |
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| Abstract: | MicroRNAs were involved in many biological processes such as growth and development,organ formation,hematogenesis, cell proliferation and apoptosis,tumor formation etc.Their mechanism of action is binding with the target messenger RNAs,and preventing them from translating into relevant proteins or just cutting the messenger RNAs into pieces.Recent studies found that microRNAs also played important roles in the modulation of skeletal muscle and cardiac muscle's growth and development;the heart's structral an... |
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| Keywords: | microRNAs gene expression cardiac remodeling |
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