| 柔性纳米脂质体对皮肤角质层结构的改变 |
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| 引用本文： | 郭健新,高凤艳,平其能.柔性纳米脂质体对皮肤角质层结构的改变[J].中国药科大学学报,2004,35(5):20-22. |
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| 作者姓名： | 郭健新 高凤艳 平其能 |
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| 作者单位： | 1. 中国药科大学药剂学教研室,南京,210009
2. 中国药科大学2001级本科毕业生 |
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| 摘 要： | 目的:研究柔性纳米脂质体对皮肤角质层结构的改变.方法:将等渗磷酸盐缓冲液(pH 7.4)、柔性纳米脂质体、胆酸钠溶液分别应用于人离体皮肤角质层和小鼠在体皮肤表面,应用扫描电镜观察角质层的结构.结果:离体条件下,柔性纳米脂质体处理过的人角质层,角质细胞间隙明显增宽.在体条件下,小鼠皮肤表面无显著性差异.结论:离体条件下,柔性纳米脂质体在角质层中的转运可能以融合扩散为主,在体条件下以穿透机制为主,且并不改变皮肤结构.
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| 关 键 词： | 柔性纳米脂质体 皮肤 角质层 透皮吸收 |
| 文章编号： | 1000-5048(2004)05-0406-03 |
| 修稿时间： | 2003年10月28 |
Structural Change of Stratum Corneum by Flexible Nano-liposomes |
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| GUO Jian-Xin,GAO Feng-Yan,PING Qi-Neng.Structural Change of Stratum Corneum by Flexible Nano-liposomes[J].Journal of China Pharmaceutical University,2004,35(5):20-22. |
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| Authors: | GUO Jian-Xin GAO Feng-Yan PING Qi-Neng |
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| Abstract: | AIM:To discover the structure change of stratum corneum with flexible nanoliposome METHOD:Isotonic phosphate buffer(pH 7 4),flexible nanoliposome and sodium cholate solution were respectively applied to cadaver stratum corneum and the mice skin Scan electron microscopy was utilized to observe the structural change RESULT:Interstices were widened up after application of flexible nanoliposomes in vitro,but there was no significant change of skin structure in situ in mice CONCLUSION:The transport mechanism was probably fusion in vitro and penetration in situ |
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| Keywords: | Flexible nano-liposomes Skin Stratum corneum Transdermal delivery |
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