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| 新疆地区甲状腺癌组织中ESR1基因表达及其临床意义的探讨 | |
| 引用本文： | 杨曦,阿仙姑·哈斯木,韶峰,武爽,阿布力孜·阿布杜拉,夏米西努尔·伊力克.新疆地区甲状腺癌组织中ESR1基因表达及其临床意义的探讨[J].癌变．畸变．突变,2010,22(3):214-217. |
| 作者姓名： | 杨曦 阿仙姑·哈斯木 韶峰 武爽 阿布力孜·阿布杜拉 夏米西努尔·伊力克 |
| 作者单位： | 1. 新疆医科大学基础医学院生物教研室,新疆乌鲁木齐,830011 2. 新疆医科大学基础医学院病理教研室,新疆乌鲁木齐,830011 3. 新疆医科大学基础医学院科研中心,新疆乌鲁木齐,830011 |
| 基金项目： | 国家自然科学基金，新疆维吾尔自治区重点实验室开放课题 |
| 摘 要： | 目的：研究雌激素受体（estrogen receptor alpha,ESR1）在新疆地区甲状腺癌组织中的表达,探讨其在临床中的意义。方法：用免疫组织化学SP法检测64例甲状腺癌、21例甲状腺良性腺瘤、13例桥本氏甲状腺炎、6例结节性甲状腺肿和6例癌旁正常组织中ESR1基因表达,结合临床病理因素进行分析。结果：ESR1在甲状腺癌组织中的阳性表达显著高于甲状腺腺瘤、桥本氏甲状腺炎、结节性甲状腺肿和癌旁正常组织（P〈0.01）;甲状腺癌组织学类型、临床分期、淋巴结转移及预后与ESR1蛋白表达相关（P均〈0.05）。结论：ESR1可能在甲状腺癌的发生、发展过程中起到了重要作用,故阻断其作用环节可能为治疗甲状腺癌提供新策略。 |
| 关 键 词： | 甲状腺肿瘤 雌激素受体 免疫组织化学 |
Expression and significance of ESR 1 in thyroid tumor tissues in Xinjiang |
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| YANG Xi,Ayshamgul.Hasim,SHAO Feng,WU Shuang,Abulizi.Abudula,Xiamixinuer.Yilike.Expression and significance of ESR 1 in thyroid tumor tissues in Xinjiang[J].Carcinogenesis,Teratogenesis and Mutagenesis,2010,22(3):214-217. | |
| Authors: | YANG Xi AyshamgulHasim SHAO Feng WU Shuang AbuliziAbudula XiamixinuerYilike |
| Institution: | YANG Xi1,Ayshamgul.Hasim2,SHAO Feng2,WU Shuang1,Abulizi.Abudula3,Xiamixinuer.Yilike1(1.Biology Department,Pre-clinical College of Xinjiang Medical University,Urumqi 830011;2.Pathology Department,Pre-clinical College of Xinjiang Medical University,Urumqi 830011;3.Molecular Biology Laboratory,Pre-clinical College of Xinjiang Medical University,Urumqi 830011,Xinjiang,China) |
| Abstract: | OBJECTIVE:To investigate the expression of estrogen receptor alpha(ESR1)in thyroid cancer tissues and explore its clinical value.METHODS:The paraffin-embedded tissue sections of 64 thyroid cancer patients,21 cases of thyroid adenoma,13 cases of Hashimoto’s thyroiditis,6 cases of nodular goiter and 6 cases from the peri-tumor tissue were immunohistochemically examined for the expression of ESR1.The association between ESR1 expression and clinico-pathological parameters were analyzed.RESULTS:The positive rate of ESR1 in thyroid cancer tissues was significantly higher than those in thyroid adenoma,Hashimoto’s thyroiditis,nodular goiter and peritumor tissues(P<0.01).The positive expression of ESR1 correlated significantly with tissue stage,clinical stage,lymph node metastasis and prognosis(P<0.05).CONCLUSION:ESR1 could play an important role in the occurrence and development of differentiated thyroid cancer,so to prevent the function of ESR1 may provide a new strategey to cure the thyroid cancer. |
| Keywords: | thyroid carcinoma ESR1 immunohistology |
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