| 99mTc-美罗华用于原发性乳腺癌前哨淋巴结活检 |
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| 引用本文： | 李囡,林保和,欧阳涛,杨志,李金锋,许小保,张岩,马云霞. 99mTc-美罗华用于原发性乳腺癌前哨淋巴结活检[J]. 中国医学影像技术, 2009, 25(4): 681-684 |
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| 作者姓名： | 李囡 林保和 欧阳涛 杨志 李金锋 许小保 张岩 马云霞 |
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| 作者单位： | 1. 北京大学临床肿瘤学院,北京肿瘤医院暨北京市肿瘤防治研究所核医学科,恶性肿瘤发病机制及转化研究教育部重点实验室
2. 乳腺癌预防治疗中心,北京,100142 |
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| 摘 要： | 目的 分析99mTc-美罗华作为示踪剂对102例原发性乳腺癌(其中1例为双乳癌)患者行前哨淋巴结(SLN)显像及活检的诊断效能. 方法 超声引导下于乳腺肿块周围及肿块表面皮下注射99mTc-美罗华后行SLN显像,并将采集到的图像与患者数码局部大体像进行图像融合.术中凭此融合图像行腋窝区前哨淋巴结活检术(SLNB).切除SLN后,行常规乳腺癌手术及腋下淋巴结清扫术,并送病理行常规HE染色及免疫组化检查. 结果 103例次SLN显像成功率100%,共显示SLN 177枚,分布于腋窝区、内乳区及乳腺组织内,平均1.72枚(177/103).腋窝区SLNB成功率99.03%(102/103),共探测到SLN 266枚,平均2.58枚(266/103).病理发现腋窝SLN有转移者76例次,转移SLN 110枚.与腋清扫淋巴结病理结果比较,SLNB的灵敏度为96.20%(76/79),特异性为100%(24/24),假阴性率为3.80%(3/79),准确率为97.09%(100/103). 结论 应用新型SLN示踪剂99mTc-美罗华行乳腺癌SLN显像及活检成功率、灵敏度及准确率高,假阴性率较低,具有临床应用价值.
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| 关 键 词： | 美罗华 乳腺肿瘤 前哨淋巴结活检 |
| 收稿时间： | 2008-04-18 |
| 修稿时间： | 2008-07-24 |
Sentinel lymph node biopsy with a novel sentinel lymphoscintigraphy agent 99mTc-Rituximab for breast cancer |
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| LI Nan,LIN Bao-he,OUYANG Tao,YANG Zhi,LI Jin-feng,XU Xiao-bao,ZHANG Yan and MA Yun-xia. Sentinel lymph node biopsy with a novel sentinel lymphoscintigraphy agent 99mTc-Rituximab for breast cancer[J]. Chinese Journal of Medical Imaging Technology, 2009, 25(4): 681-684 |
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| Authors: | LI Nan LIN Bao-he OUYANG Tao YANG Zhi LI Jin-feng XU Xiao-bao ZHANG Yan MA Yun-xia |
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| Affiliation: | Department of Nuclear Medicine,;Department of Nuclear Medicine,;Breast Cancer Perevntion and Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology,Beijing Cancer Hospital & Institute, Bejing 100142, China;Department of Nuclear Medicine,;Breast Cancer Perevntion and Treatment Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology,Beijing Cancer Hospital & Institute, Bejing 100142, China;Department of Nuclear Medicine,;Department of Nuclear Medicine,;Department of Nuclear Medicine, |
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| Abstract: | |
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| Keywords: | Rituximab Breast neoplasms Sentinel lymph node biopsy |
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