Serum level of major basic protein indicates disease activity in atopic dermatitis |
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| Authors: | Kouichi Ikai Naoko Nakajima Motoaki Ozaki Ikuko Furukawa Toshiyuki Aoshima Tsuneo Mitani Mari Sawami Shigetoshi Sayama Mitsuyoshi Omoto Masami Uehara Sadao Imamura |
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| Affiliation: | Department Of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan;Department of Dermatology, Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan;Department of Dermatology, Otsu Red Cross Hospital Shiga, Japan;Department of Dermatology, Kansaidenryoku Hospital, Osaka, Japan;Department of Dermatology, Tenri Hospital, Nara, Japan;Department of Dermatology, Shiga University of Medical Science, Shiga, Japan |
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| Abstract: | We evaluated the serum levels of major basic protein (MBP), assayed using an MBP radioimmunoassay kit. and the effect of an anti-allergic agent, ketotifen, which has strong anti-eosinophil activity, in 56 atopic dermatitis (AD) patients. The serum MBP level was significantly lower (660.11 ± 34.52 ng/ml, P < 0.05) after administration of ketotifen (1 mg twice a day) for 8 weeks than before treatment (774.98 ± 48.64 ng/ml). These findings suggest that serum MBP levels are a useful indicator of AD activity and that anti-allergic agents can have an effect on eosinophil involvement in AD. |
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| Keywords: | Major basic protein Eosinophil Atopic dermatitis Radioimmunoassay Anti-allergic agent Ketotifen |
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