| 重组人白介素6对SW872脂肪细胞促酰化蛋白分泌的影响 |
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| 引用本文： | 张龙江,卢慧玲,林汉华,王宏伟,杨杨,温宇. 重组人白介素6对SW872脂肪细胞促酰化蛋白分泌的影响[J]. 中华内分泌代谢杂志, 2006, 22(3): 279-280 |
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| 作者姓名： | 张龙江 卢慧玲 林汉华 王宏伟 杨杨 温宇 |
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| 作者单位： | 1. 深圳市南山人民医院儿科,518052
2. 430030,武汉,华中科技大学同济医学院附属同济医院儿科 |
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| 基金项目： | 国家自然科学基金资助项目（No.30170442）;国家自然科学基金国际合作交流项目（No.30311120163）. |
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| 摘 要： | 体外培养SW872细胞，油酸诱导其分化为成熟的脂肪细胞，然后加入重组人白细胞介素6（IL-6）观察其对SW872成熟脂肪细胞促酰化蛋白（ASP）分泌的影响。结果显示0．6mmoL／L油酸刺激72h能成功诱导SW872前脂肪细胞分化为成熟的脂肪细胞；IL-6对SW872成熟脂肪细胞ASP的分泌具有明显的抑制作用，且表现为时间和剂量依赖效应。
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| 关 键 词： | SW872细胞 脂肪细胞 细胞分化 油酸 白细胞介素6 促酰化蛋白 |
| 收稿时间： | 2004-10-29 |
| 修稿时间： | 2004-10-29 |
Effect of recombinant human interleukin-6 on the secretion of acylation-stimulating protein in SW872 adipocytes |
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| ZHANG Long-jiang,LU Hui-ling,LIN Han-hua,WANG Hong-wei,YANG Yang,WEN Yu. Effect of recombinant human interleukin-6 on the secretion of acylation-stimulating protein in SW872 adipocytes[J]. Chinese Journal of Endocrinology and Metabolism, 2006, 22(3): 279-280 |
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| Authors: | ZHANG Long-jiang LU Hui-ling LIN Han-hua WANG Hong-wei YANG Yang WEN Yu |
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| Affiliation: | Department of Pediatrics, Tongji Hospital, Tongji Medical college, Huazhong University of Sicence and Technology, Wuhan 430030 |
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| Abstract: | SW872 cells were cultured in vitro with oleic acid and differentiated into mature adipocytes. The role of interleukin-6(IL-6)in the secretion of acylation-stimulating protein(ASP)in mature SW872 adipocytes was observed.The results suggested that IL-6 significantly inhibited ASP secretion into the media in a dose-and time-dependent manner in mature SW872 adipocytes. |
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| Keywords: | SW872 cells Adipocytes Cell differentiation Oleic acid Interleukin-6 Acylation- stimulating protein |
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