Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients |
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Authors: | M Plotkin H Amthauer S Klaffke A Kühn L Lüdemann G Arnold K-D Wernecke A Kupsch R Felix S Venz |
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Institution: | (1) Klinik für Strahlenheilkunde, Campus Virchow-Klinikum, Charité Universitätsmedizin, Berlin, Germany;(2) Klinik für Neurologie, Campus Virchow-Klinikum, Charité Universitätsmedizin, Berlin, Germany;(3) Institut für medizinische Biometrie, Campus Virchow-Klinikum, Charité Universitätsmedizin, Berlin, Germany |
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Abstract: | Summary. 72 consecutive patients with suspected parkinsonian syndromes (PS) were studied by dopamine transporter (DAT) and D2 receptor SPECT in order to evaluate the accuracy of combined SPECT imaging. In the follow-up, the patients were diagnosed as having Parkinson s disease (PD, n = 25), dementia with Lewy bodies (DLB, n = 6), multiple system atrophy (MSA, n = 13), progressive supranuclear palsy (PSP, n = 8), corticobasal degeneration (CBD, n = 9), and essential tremor (ET, n = 11). Using the iteratively estimated optimal cutoffs, DAT was reduced in 57/61 PS patients, whereas all ET patients were identified as normal . Reduced D2 receptor binding had 7/13 patients with MSA, 6/8 patients with PSP, 2/9 patients with CBD and no ET, PD or DLB patients. FP-CIT SPECT allows an accurate detection of nigrostriatal affection in neurodegenerative PS. IBZM SPECT is useful to approve the diagnosis of PSP and MSA although a normal finding cannot exclude an atypical PS. IBZM SPECT seems to be of restricted value in CBD. |
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Keywords: | : Parkinsonian syndromes [123]I-FP-CIT [123]I-IBZM single photon emission tomography (SPECT) |
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