利凡诺及利凡诺联合米非司酮在妊娠中期引产中的临床疗效分析简

目的 探讨利凡诺及利凡诺联合米非司酮对中期妊娠引产的临床疗效.方法 随机选择2011年6月～2012年12月来武汉大学中南医院就诊的100例妊娠中期引产患者,将其平均分成两组,每组50例,一组接受经羊膜腔注入利凡诺100 mg（利凡诺组）,另一组口服米非司酮150 mg,同时经羊膜腔注入利凡诺100 mg（联合用药组）.采用SPSS17.0统计软件,利用t检验和x2检验统计方法对两组在患者年龄、胎龄、引产时间、成功引产率等方面进行比较.结果 联合用药组的平均引产时间为（16.6±6.9）h,明显少于利凡诺组[（30.1±13.3）h]（P＜0.001）.联合用药组有42例（84％）完全引产,50例（100％）成功引产,而利凡诺组有35例（70％）完全引产,45例（90％）成功引产,差异均有统计学意义（P＜0.05）.结论 利凡诺联合米非司酮在妊娠中期引产时可以缩短引产时间,提高了引产成功率,同时减少了并发症的发生.

Clinical analysis of Ethacridine mixed with Mifepristone in second trimester abortion compared to Ethacridine alone

Objective To study the clinical efficacy of combination of Mifepristone with Ethacridine in second trimester abortion as compared to Ethacridine alone.Methods 100 patients undergoing second trimester abortion in the Zhongnan Hospital of Wuhan University from June 2011 to December 2012 were randomly divided into two groups.50 patients received extra-amniotic Ethacridine lactate 100 mg through Foley＇s catheter （Ethacridine group）,and the other 50 patients received 100 mg extra-amniotic Ethacridine lactate mixed with 150 mg Mifepristone through Foley＇s catheter （combination group）.The difference of mean age,gestational age,induction time and induction rates were comparable in both the groups using the method t test ad x2 test with the software SPSS 17.0.Results The instillation-abortion interval was significantly shorter in combination group as compared to Ethacridine group [（16.6±6.9） h vs （30.1± 13.3） h] （P ＜ 0.001）.The cases of completely induced labor were 42 （84％）,and the success cases of induced labour were 50 （100％） in combination group,as compared to 35 cases （70％） of completely induced labor and 45 cases （90％） of success in Ethacridine group,the results were statistical significance （P ＜ 0.05）.Conclusion Addition Mifepristone in extra-amniotically instilled ethacridine lactate can reduce the instillation-abortion interval significantly and increased the success rate,while reduce the complications.