2 型糖尿病高血糖与炎症两者联合对血管病变的影响简

目的探讨2型糖尿病患者高血糖与炎症两者联合对血管病变的影响。方法选择2011年10月-2013年6月桂林市第二人民医院内分泌科收治的2型糖尿病住院患者480例为研究对象，根据检查结果将其分为糖尿病合并大血管病变及微血管病变组（A组），糖尿病合并大血管病变组（B组），糖尿病合并微血管病变组（C组），糖尿病无血管病变组（D组），选取同期健康体检者80例作为对照组，计算并比较两组糖化血红蛋白（HbAk）与超敏C反应蛋白（hsCRP）的乘积，比较各组间（HbA1c×hsCRP）差异，并统计（HbA1c×hsCRP）各四分位组血管并发症的发生率。结果A组（HbA1c×hsCRP）（26．56±6．25）显著高于B组（23．12±5．42）和C组（22．78±4．98），B组、C组显著高于D组（15．26±4．08），D组显著高于对照组（5．17±1．39），差异有统计学意义（P〈0．05），B组和C组间差异无统计学意义（P〉0．05），（HbA1c×hsCRP）最高四分位数组血管并发症发生率88．9％（40／45）显著高于最低四分位数组35．9％（83／231），差异有高度统计学意义（P〈0．01）。结论高血糖与炎症的联合作用，促进糖尿病血管并发症的发生、发展。

Influence of hyperglycemia combined with inflammation on vascular dis- ease of type 2 diabetes

Objective To discuss the impact of hyperglycemia combined with inflammation on vascular disease of type 2 diabetes. Methods 480 patients with type 2 diabetes from October 2011 to June 2013 in the Second People＇s Hospi- tal of Guilin City were selected as study objects, according to the test result, they were divided into diabetes combined with macroangiopathy and microangiopathy group （group A）, diabetes combined with macroangiopathy group （group B）, diabetes combined with microangiopathy group （group C） and diabetes without vascular disease group （group D）, 80 healthy people in the same period were selected as control group. HbA1c× hsCRP of each group was counted and com- pared. Occurrence rate of vascular complications of each quartile groups of （HbA1c× hsCRP） was counted. Results （HbA1c× hsCRP） of group A （26.56±6.25） was obviously higher than group B （23.12±5.42） and group C （22.78±4.98）, group B and C were obviously higher than group D （5.17±1.39）, group D was obviously higher than control group, the differences were statistically significant （P 〈 0.05）. No significant difference existed between group B and C （P 〉 0.05）. Occurrence rate of vascular complications of the highest quartile group 88.9% （40/45） was obviously higher than the lowest quartile group 35.9% （83/231）, the difference was high statistically significant （P 〈 0.01）. Conclusion Combina- tion of hyperglycemia and inflammation can promote occurrence and progress of vascular complications of diabetes.