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A Novel Morbidity Prediction Model for Head and Neck Oncosurgery
Authors:Mary Thomas  Nebu Abraham George  Balagopal Prabhakar Gowri  Preethi Sara George  Paul Sebastian
Affiliation:(1) Department of Anesthesiology, Regional Cancer Centre, Medical College Campus, Thiruvananthapuram, Kerala, 695011, India;(2) Department of Surgical Oncology, Regional Cancer Centre, Medical College Campus, Thiruvananthapuram, Kerala, India;(3) Department of Biostatistics, Regional Cancer Centre, Medical College Campus, Thiruvananthapuram, Kerala, India
Abstract:The purpose of the study was to construct and validate a risk model to predict morbidity in head and neck oncosurgeries. Potential risk factors of 300 surgically treated head and neck cancer patients like age, sex, tumor site, TNM stage, duration of surgery, adjunctive treatment, comorbidities and alcohol and tobacco usage were analyzed. Postoperative complications were noted. We developed a logistic model to predict the probability of patients developing morbidity based on the statistically significant variables-duration of surgery, preoperative radiation and hypertension. The validity of the test was assessed by the c-index which were 0.79 (95% C.I 0.71–0.87) for the study set (250 patients) and 0.86(95% C.I 0.73–0.90) for the test set (50 patients). The correlation of observed to expected morbidity was 0.709 (P < 0.0001). We validated a risk model and constructed a simple chart that provides us an assessment of the risk of a patient of developing morbidity.
Keywords:Head and neck cancer   Surgery   Risk factors   Morbidity prediction
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