| 缺血/低氧相关疾病微小RNA-210研究进展 |
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| 引用本文： | 史雨晨,刘翠英,李俊发.缺血/低氧相关疾病微小RNA-210研究进展[J].基础医学与临床,2013,33(2):227-230. |
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| 作者姓名： | 史雨晨 刘翠英 李俊发 |
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| 作者单位： | 首都医科大学神经生物学系,北京,100069 |
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| 基金项目： | 国家自然科学基金(30871219,31071048,31171147);科技部973计划前期研究专项(2011CB512109);教育部高等学校博士点科研基金(20091107110001) |
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| 摘 要： | 缺血/低氧是临床许多疾病的病理生理过程之一，而miRNA-210以其在缺血/低氧状态下的稳定性和功能的多样性引起了人们广泛关注。本文分析了在缺血/低氧状态下miRNA-210对线粒体新陈代谢和血管生成的影响；并且进一步阐述了miRNA-210在心肌梗死，中风和肿瘤等缺血/低氧性损伤疾病中的作用。
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| 关 键 词： | miRNA-210 缺血/低氧性损伤 癌症 线粒体新陈代谢 血管发生 |
Research advance on the role of miRNA-210 in the ischemic/hypoxic pathogenesis |
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| SHI Yu-chen#,LIU Cui-ying,LI Jun-fa.Research advance on the role of miRNA-210 in the ischemic/hypoxic pathogenesis[J].Basic Medical Sciences and Clinics,2013,33(2):227-230. |
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| Authors: | SHI Yu-chen# LIU Cui-ying LI Jun-fa |
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| Institution: | *(Dept.of Neurobiology,Capital Medical University,Beijing 100069 China) |
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| Abstract: | Ischemia/hypoxia is one of the common pathophysiological processes in many clinic diseases. The stabilities and diverse functions of miRNA-210 in ischemic / hypoxic state have been caused widespread concern. This article analyzes the effects of miRNA-210 on mitochondrial metabolism and angiogenesis in the ischemic / hypoxic state; then, attention is focus on the roles of miRNA-210 in ischemic / hypoxic diseases, such as myocardial infarction, stroke and cancer. |
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| Keywords: | [Keywords] miRNA-210 ischemic/hypoxic injuries cancer mitochondria metabolism angiogenesis |
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