Association between a dimorphic site on chromosome 12 and clinical diagnosis of hypertension in three independent populations |
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Authors: | Philippe M. Frossard Gilles G. Lestringant |
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Affiliation: | Department of Pathology, F.M.H.S., Al Ain, U.A.E.;Department of Internal Medicine, Tawam Hospital, Al Ain, U.A.E. |
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Abstract: | With the aim of identifying putative quantitative trait loci (QTLs) involved in the regulation of blood pressure, we have carried out association studies at a candidate genetic locus - a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12. Positive associations were found between the presence of a Taq I dimorphic site localized in the first intron of this gene and hypertension in three sample populations (two from USA and one from Germany). These results indicate that a QTL implicated in determining an individual's genetic susceptibility to hypertension could be present within up to 30 cM of this human PLA2 gene. |
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Keywords: | association study human phospholipase A2 gene hypertension RFLP |
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