血清胱抑素C在糖尿病肾功能检测中的意义

目的探讨血清胱抑素C(Cys-C)在糖尿病肾功能检测中的意义。方法将研究对象分为2型糖尿病肾病组45例及健康体检正常者45例。Cys-C检测采用乳胶颗粒散射比浊法测定,β2-MG测定采用免疫比浊法,血肌酐(Scr)采用肌酐酶法测定,尿素氮(BUN)检测采用尿酶-谷氨酸脱氢酶法测定。检验项目均由AU-2700全自动生化分析仪测定。结果糖尿病肾病组Cys-C、β2-MG、Scr和Bun均明显高于健康对照组,差异有统计学意义(P<0.05)。结论 Cys-C是糖尿病肾病早期诊断和治疗的理想指标,早期监测能早期发现病情,对于改善患者预后和提高生活质量具有重要的临床意义。

Significance of serum cyctation C in detection of diabetic renal

Objective To investigate the significance of serum cystatin C(Cys-C) in the detection of diabetic renal function.Methods The subjects were divided into 45 cases of normal and 45 cases of type 2 diabetic nephropathy.Cys-C was detected by latex particle scattering turbidimetric method of β2-MG was determined by immune turbidimetry,serum creatinine(Scr) and creatinine enzymatic determination of blood urea nitrogen(BUN) were detected by urinary enzymes-glutamate dehydrogenase determination.The test items determined by the AU-2700 automatic biochemical analyzer.Results Diabetic nephropathy group of Cys-C and β2-MG,Scr and Bun were significantly higher than those in the healthy control group,the difference was statistically significant(P<0.05).Conclusions Cys-C is an ideal indicator of early diagnosis and treatment of diabetic nephropathy,early detection of disease can improve patient outcomes and improve quality of life,it has important clinical significance.