盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒疗效比较研究

目的比较盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒的临床疗效。方法 76例6h内有机磷农药中毒者随机分成盐酸戊乙奎醚组(38例)和阿托品组(38例),均配伍用氯解磷定,分别按照胆碱酯酶数值划分的轻中重度程度,给予不同剂量的盐酸戊乙奎醚及阿托品,比较两组患者的临床疗效。结果盐酸戊乙奎醚组的中毒症状消失时间、治愈时间、CHE恢复时间与阿托品组比较,差异均有统计学意义(P<0.01);并且不良反应的发生率明显比阿托品组低(P<0.01)。结论盐酸戊乙奎醚治疗急性有机磷农药中毒疗效确切,不良反应少,优于阿托品。

Comparative study of penehyclidime hydrochloride and atropine in treatment of acute organophosphate pesticide poisoning

Objective To compare the clinical efficacy of penehyclidime hydrochloride and atropine in treatment of acute organophosphate pesticide poisoning.Methods Totally 76 patients within six hours of organophosphorus pesticide poisoning were randomly divided into penehyclidime hydrochloride group(n=38) and atropine group(n=38),they were all combined with pralidoxime chloride,different doses of penehyclidime hydrochloride and atropine were given according to difference degrees of severity which was ranged in terms of cholinesterase value.The clinical efficacy of two groups was compared.Results The penehyclidime hydrochloride group,the poisoning symptoms time,cuative time and CHE recovery time were compared with that of the atropine group,the difference was statistically significant(P<0.01);The incidence rate of adverse reactions significantly less than that of the atropine group(P<0.01).Conclusion Penehyclidime hydrochloride in treatment of acute organophosphate pesticide poisoning is safer and more effective than atropine.