Ecalectin/galectin-9, a novel eosinophil chemoattractant: its function and production |
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Authors: | Hirashima M |
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Institution: | Department of Immunology and Immunopathology, Kagawa Medical School, Kagawa, Japan. mitsuomi@kms.ac.jp |
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Abstract: | We have recently succeeded in purifying and cloning a novel eosinophil chemoattractant, ecalectin/galectin-9, which belong to a rapidly growing galectin family. The eosinophil chemoattractant activity of ecalectin is potent and selective for eosinophils. The cellular source of ecalectin has been thought to be antigen-stimulated T cells. Herein, we will review the significance of its divalent galactoside-binding activity in ecalectin-induced eosinophil chemoattraction and the regulation of ecalectin expression in immune cells. |
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