谷氨酰胺颗粒剂对严重烧伤患者的疗效及安全性分析

目的 :评价谷氨酰胺颗粒剂对严重烧伤后肠道损害的疗效及安全性。方法 :采用随机双盲对照法 ,将受试患者分为治疗组 (20例 )和对照组 (19例 ) ,治疗组口服谷氨酰胺颗粒剂30g/天 ,每天3次 ,对照组口服同等剂量的安慰剂。观察两组患者血浆谷氨酰胺含量、肠粘膜受损程度、肝肾功能及并发症等 ,并比较患者创面愈合情况和住院天数。结果 :治疗组患者用药7天后 ,血中谷氨酰胺含量分别较用药前和对照组升高了37 87 %和37 86 % (P<0 01)。治疗组与对照组相比 ,一般情况较好 ,肠道损害程度明显减轻 ,肠粘膜通透性降低 ,创面愈合较快 ,住院天数明显缩短。所有受试者无1例因不良反应而停药 ,无1例死亡。结论 :服用谷氨酰胺颗粒剂能显著减轻烧伤后患者肠道受损程度 ,保护肠粘膜屏障 ,促进创面愈合 ,且无明显不良反应。

Analysis of the Efficacyand Safety of L-Glutamine Granules in Treating Severe Burn Patients

OBJECTIVE:To evaluate the clinical therapeutic effect of L-glutamine granules on intestinal damage of severe burn patients and the safty of the drug METHODS:Thirty-nine severe burn patients were randomly divided into two groups:control group(C group,nineteen patients)and L-glutamine treatment group(GLN group,twenty patients) GLN group patients were given L-glutamine in a dose of 30g per day for 7 days,and C group patients were given the same dosage of placebo for 7 days The plasma L-glutamine concentration,the degree of intestinal mucosa damage,blood biochemistry and complication were observed and wound healing rate of burn area was determined,then the length of hospital stay was recorded RESULTS:After 7 days of taking L-glutamine orally,plasma L-glutamine concentration in GLN group was significant higher than that in C group(P<0 01) The degree of intestine damage and intestinal mucosal permeability in GLN group were lower than those in C group In addition,the wound healing rate was faster and the length of hospital stay was shorter in GLN group than those in C group CONCLUSION:Administration of L-glutamine could abate the degree of intestine damage obviously,lessen intestinal mucosal permeability,ameliorate wound healing rate and reduce the length of hospital stay