益气消痞汤治疗脾胃虚弱型慢性萎缩性胃炎临床观察

目的观察益气消痞汤治疗脾胃虚弱型慢性萎缩性胃炎的临床疗效。方法将160例脾胃虚弱型慢性萎缩性胃炎患者随机分为2组。治疗组80例应用自拟益气消痞汤治疗,对照组80例应用摩罗丹治疗,2组均5周为1个疗程,连续应用2个疗程。观察2组治疗前后临床主要症状、体征,胃镜及病理组织学分级的变化,以及主要症状积分改变情况。结果治疗组总有效率为92.5%,对照组总有效率为77.5%,2组比较差异有统计学意义(P<0.05);且治疗后2组患者除胃脘痞胀外其他症状积分变化比较差异均有统计学意义(P<0.05),提示治疗组在改善喜暖喜按、饮食减少、嗳气方面优于对照组。结论益气消痞汤治疗脾胃虚弱型慢性萎缩性胃炎能显著改善临床症状,逆转幽门螺杆菌(Hp)感染、胃黏膜萎缩等病理组织学分级,远期疗效较好。

Clinical observation of Yiqixiaopi decoction on the treatment of chronic atrophic gastritis with weakness of the spleen and the stomach type

Objective To study the clinical effect of Yiqixiaopi decoction on the treatment of the chronic atrophic gastritis with the type of deficiency of spleen and stomach.Methods 160 cases of patients with chronic atrophic gastritis with weakness of the spleen and the stomach type were randomly divided into two groups.Patients in treatment group（n=80） were treated by Yiqixiaopi decoction.Patients in control group（n=80） were treated by Moluodan.The therapeutic course was 5 weeks in both groups.The effect was evaluated by two courses.The main clinical symptom,physical sign,the differences of the endoscope examination,the pathohistologic grading,and the integral of the main symptoms were observed before and after the treatment.Results The total effective rate in treatment group（92.5%） was obviously higher than that in control group（77.5%）.There was a statistic difference（P0.05）.After the treatment,there was a statistical difference（P0.05） in the integral of the main symptoms,except for stomach swelling of expansion.It means that the treatment group is better compared to the control group in the improvement of warm-blooded,reducing diet,belching.Conclusion Yiqixiaopi decoction can significantly improve clinical symptoms,reversal of Helicobacter pylori（Hp） infection,gastric atrophy and other histological grade on the treatment of chronic atrophic gastritis with the type of deficiency of spleen and stomach,Yiqixiaopi decoction has a better long term effect on the chronic atrophic gastritis.