99m锝-二乙三胺五乙酸气溶胶肺通气指数在慢性阻塞性肺疾病肺功能评估中的价值

目的研究99m锝-二乙三胺五乙酸(Tc-DTPA)气溶胶肺通气显像的通气指数(ventilation index,VI)与慢性阻塞性肺病(COPD)肺功能之间的关系。方法 42例COPD患者均行气溶胶肺通气显像和COPD肺功能分级。肺通气显像结束后,利用感兴趣区(region of interest,ROI)技术分析左右肺中央带、周围带的放射性分布情况,并计算得到VI。分析肺功能分级和VI之间的关系。结果 VI≥50%组第1秒用力呼气容积(FEV1%)和FEV1/用力肺活量(FVC)分别为:(51.8±18.2)%和(60.0±11.9)%,VI<50%组FEV1%和FEV1/FVC分别为(40.5±13.0)%和(51.7±9.3)%,两组之间差异有统计学意义(P<0.05)。且FEV1%和VI之间有很好的相关性(r=0.391,P<0.05),FEV1/FVC与VI之间也有很好的相关性(r=0.517,P<0.01)。但FVC与VI之间无相关性(r=0.123,P>0.05)。结论 VI和COPD肺功能分级之间有很好的相关性。VI可直接和准确的预测和显示肺内的气体分布。联合应用VI和COPD分级能更准确的评估肺功能。

Role of 99mTc-DTPA radioaerosol pulmonary ventilation index in chronic obstructive pulmonary disease patients

Objective To determine if correlation exists between the pulmonary scintigraphy ventilation index（VI） and lung function classification in chronic obstructive pulmonary disease（COPD）. Methods 42 COPD patients,aged 52 to 73 years old,average age（66.0±8.2） years old,30 males,12 females,were evaluated by the pulmonary scintigraphy VI and COPD lung function classification.After the pulmonary scintigraphy,central to unilateral lung ratios of left lung and right lung were calculated by region of interest（ROI） method.The ratios were calculated for VI.Correlations were calculated between VI and lung function classification. Results The FEV1% and FEV1/FVC of VI≥50% group were（51.8±18.2）% and（60.0±11.9）% respectively.The FEV1% and FEV1/FVC of VI〈50% group were（40.5±13.0）% and（51.7±9.3）% respectively. There were correlations between VI and FEV1%（r=0.391,P〈0.05）,between VI and FEV1/FVC（r=0.517,P〈0.01）.There was no correlation between VI and FVC（r=0.123,P〉0.05）. Conclusion The results show that there is correlation between VI and COPD lung function classification.VI may predict more directly and accurately the diffusion of gas in the lung.The combined application of VI and COPD classification can more accurately evaluate lung function.