| HPLC法测定三磷酸胞苷二钠注射液的含量 |
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| 引用本文： | 徐菁. HPLC法测定三磷酸胞苷二钠注射液的含量[J]. 湖北中医药大学学报, 2008, 10(3): 57-58 |
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| 作者姓名： | 徐菁 |
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| 作者单位： | 武汉大学研修班,湖北中医学院药学院药物分析教研室,湖北,武汉,430065 |
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| 摘 要： | 目的建立三磷酸胞苷二钠注射液含量测定方法。方法采用高效液相色谱法，以十八烷基键合硅胶为填充柱；检测波长：271nm；流动相：0．2mol／L磷酸盐缓冲液；柱温：35℃。结果此法可使三磷酸胞苷二钠与二磷酸胞苷二钠、一磷酸胞苷二钠得到非常好的分离。结论本法操作简便、快速、准确，适用于本制剂的质量控制。
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| 关 键 词： | 三磷酸胞苷二钠 高效液相色谱法 含量测定 |
HPLC Method for Determining the Concentrations of Sodium Cytidine Triphosphate in Cytidinedisodium triphosphate Injection |
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| XU Jing. HPLC Method for Determining the Concentrations of Sodium Cytidine Triphosphate in Cytidinedisodium triphosphate Injection[J]. Journal of Hubei University of Chinese Medicine, 2008, 10(3): 57-58 |
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| Authors: | XU Jing |
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| Affiliation: | XU Jing (Wuhan University, Hubei College of Traditional Chinese Medicine , Wuhan, Hubei, 430065) |
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| Abstract: | Objective： To establish a HPLC method for determining the concentrations of sodiumcytidine triphosphate （CTP） in cytidine disodium triphosphate injection. Method： ODS C18 colunm was applied, detection wavelength was 271nm , the mobile phase was 0.2mol/L, the column temperature was 35℃. Results： To segregate sodiumcytidine triphosphate, sodium cytidine diphosphate and sodium cytidine monophosphate successfully. Conxlusion： This method is simple, fast and accurate and is suitable for the quality control of the preparation. |
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| Keywords: | sodium cytidine triphosphate HPLC determination |
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