Rotavirus gastroenteritis‐associated urinary ammonium acid urate crystals |
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| Authors: | Tadafumi Yokoyama Naotoshi Sugimoto Eiji Kato Kazuhide Ohta Sayaka Ishikawa Kazuyuki Ueno Masaki Shimizu Akihiro Yachie |
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| Institution: | 1. Department of Pediatrics, Fukuiken Saiseikai Hospital, Fukui, Fukui, Japan;2. Department of Physiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan;3. Department of Pediatrics, National Health Organization, Kanazawa Medical Center, Kanazawa, Ishikawa, Japan;4. Department of Pediatrics, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan |
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| Abstract: | Although ammonium acid urate (AAU) calculi are extremely rare renal stone components, it was recently found that many urinary tract calculi that cause post‐renal renal failure in rotavirus (RV) gastroenteritis are AAU calculi. The mechanism of AAU calculi development in RV gastroenteritis has not been fully elucidated. We analyzed data from eight RV gastroenteritis patients who transiently had AAU crystals in their urinary sediment. In these patients, formation of AAU crystals occurred earlier than the formation of AAU calculi. No difference was observed in serum and urine uric acid levels between RV gastroenteritis patients with or without AAU crystals. Interestingly, fractional excretion of sodium was extremely low among patients with AAU crystals. These results suggest that the formation of AAU crystals might not be due to excretion of uric acid, but excretion of sodium. |
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| Keywords: | ammonium acid urate crystal excretion of sodium rotavirus gastroenteritis urinary sediment |
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