37例格林－巴利综合征患者血清抗空肠弯曲菌脂多糖抗体检测

已有许多研究证实格林－巴利综合征（ＧＢＳ）与前驱空肠弯曲菌（Ｃｊ）感染有密切关系。但是，Ｃｊ诱发ＧＢＳ的病理机制仍不明确。作者试图探讨Ｃｊ菌体成份与ＧＢＳ发病的关系。以一株自ＧＢＳ患者分离得到的Ｃｊ之脂多糖（ＬＰＳ）为抗原，用酶联免疫吸附试验（ＥＬＩＳＡ）方法，检测了ＧＢＳ患者组（观察组）和健康成人组（对照组）的血清抗空肠弯曲菌脂多糖抗体。结果ＧＢＳ组血清呈阳性反应者为２０／３７（５４％）、对照组血清呈阳性反应的为１／３６（３％），差别具有统计学意义（Ｐ＜０．００１，ｘ２）。提示多数ＧＢＳ患者血清中存在着不同于健康人群的ＣｊＬＰＳ特异抗体．

Serum Antibodies against lipoplysaccharides of Campylobacter jejuni in 37 Patients with Guillain-Barre syndrome

Guillain-Barre syndrome (GBS) is the common cause of acute flaccid paralysis (AFP) in both adult and children today. Recently, some reports suggest that antecedent infection with Campylobacter jejuni (Cj) is closely associated with GBS. The pathogenesis of the Cj infection eliciting GBS remains unknown. Our purpers was truing to find relations between component of Cj and GBS. An Enzyme-Linked Immunosorbent Assay (ELISA) was performed for detection of IgG, IgM antibody using lipopolysaccharides (LPS) of Cj which were isolated from a patient with GBS as antigens (LL-LPS). A total of 37 sers from patients with GBS and 36 sera from a contral group were tested. The results shows 20/37(54 % ) sera of the patients with GBS developed antibodies against LL-LPS while allbut one of the control group have no specific antibodys (3% ). There are differences between GBS group and control group on statistics (P<0. 001, x2). We conclud that there are special antibodts against LL-LPS in sera of many patients with GBS.