BALB/c小鼠感染广州管圆线虫后脑内的动态变化

目的观察广州管圆线虫感染BALB/c小鼠后其虫数在小鼠脑内的动态变化,探讨其感染后对人体可能的致病机制。方法以广州管圆线虫Ⅲ期幼虫感染实验BALB/c小鼠,按感染的不同时间分批处死,镜下及肉眼观察脑内虫体数量及分布情况。结果在BALB/c小鼠大、小脑内,广州管圆线虫的分布符合寄生虫感染宿主后先增后减的一般基本变化规律,虫体寄生的部位因感染虫体而受损。引起症状的时间变化与虫体在脑内变化规律基本相符。结论小鼠感染广州管圆线虫以后,出现共济失调,抽搐等症状的时间与虫体在小鼠脑内的变化规律基本相符。为临床研究该病的相关临床症状及治疗提供了一定的实验依据。

Dynamic change of parasites in the brains of BALB/c mice infected with Angiostrongylus cantonensis

To observe the dynamic change of parasites in the brains of BALB/c mice infected with Angiostrongylus cantonensis in order to explore its possible mechanism of pathogenesis＇, BALB/c mice infected with the Ⅲ stage larvae of A. cantonensis were observed and killed in different times after infection. The number and distribution of parasites in the brains of the infected mice were observed microscopically and macroscopically. It was found that the larvae of A. cantonensis were distributed in the cerebrum and cerebellum of mice in accordance with the rule of parasitization of worms in the host, i. e. multiplication at first and then dropping in number. And the places where the parasites located were damaged due to mechanical action or inflammatory reactions. The time of onset of symptoms, such as ataxia and twitch was coincided with the dynamic changes in the brains of the infected mice.