胎盘提前钙化的超声征象与胎盘功能的关系

目的:了解胎盘提前钙化的超声征象与胎盘功能的关系。方法:选择15例在36周前B超检查发现Ⅲ级胎盘成熟度的低风险孕妇作为研究组,随机选择同期分娩孕龄与研究对象相匹配的正常孕妇15例作为对照。检测两者的多普勒脐血流、母血游离E3(FE3)浓度,分娩后留胎盘行HPL的免疫组化染色并对染色情况进行定量分析。结果:两组的母血FE3浓度无统计学差异〔8.97(4.7,12.25)ng/ml vs 9.195.54,11.65 ng/ml,P>0.05〕,两组胎盘内HPL的表达强度无统计学差异〔19.85(18.20,19.91)PUvs 20.17(18.01,22.56)PU,P>0.05〕,但胎盘提前钙化组的脐动脉血流的搏动指数(PI)及脐动脉收缩期最大血流速度(S)与舒张期血流速度(D)的比值(S/D)显著高于对照组〔(0.79±0.17)vs(0.71±0.09)P<0.05〕和〔(2.34±0.38)vs(1.99±0.17),P<0.001〕。结论:提前钙化胎盘的分泌功能尚正常,但脐血流受到影响,应引起注意。

Relationship between ultrasonic signs of placental premature calcification and placental function

Objective:To understand the relationship between ultrasonic signs of placental premature calcification and placental function.Methods:Fifteen low risk pregnant women with maturity of grade Ⅲ placenta found by ultrasonography before 36 gestational weeks were selected as study group,and 15 normal pregnant women which had the same gestational weeks and were matched to the study objects in study group were randomly selected as control group.Doppler umbilical cord blood flow and maternal blood fasting estriol concentration were detected;after delivery,placental HPL immunohistochemical staining was performed,and the staining status was analyzed quantificationally.Results:The maternal blood estriol concentrations in the two groups were 8.97(4.7-12.25) ng/ml and 9.19(5.54-11.65) ng/ml,respectively,there was no statistically significant difference(P>0.05);the expression levels of placental HPL in the two groups were 19.85(18.20-19.91) PU and 20.17(18.01-22.56) PU,respectively,there was no statistically significant difference(P>0.05);the pulsalitity index(PI) and the ratio of peak systolic flow velocity/peak diastolic flow velocity of umbilical artery in study group were(0.79±0.17) and(2.34±0.38),respectively,which were statistically significantly higher than those in control group((0.71±0.09) and(1.99±0.17))(P<0.05)(P<0.001).Conclusion:The secreting function of placentas with premature calcification is normal,but blood flow of umbilical artery is affected,so more attention should be paid to the phenomenon.