新生儿高胆红素血症对早产儿肾功能的影响

目的:探讨血清胱抑素-C(Cys-C)在评估高胆红素血症早产儿肾功能损伤中的价值。方法:选择113例早产儿为研究对象,按胆红素程度分为轻度组(25例)、中度组(15例)及重度组(11例),其中胆红素在正常范围者为对照组(62例)。所有早产儿在生后3天至1周内抽取静脉血2 ml,采用免疫比浊法检测血清Cys-C水平,同时检测血清尿素氮(BUN)及肌酐(Cr)。应用SPSS 11.0软件进行统计学分析。结果:重度组与对照组、中度组与对照组患儿之间血清Cys-C的差异均有统计学意义(P<0.01);重度组与中度组、重度组与轻度组、中度组与轻度组患儿之间血清Cys-C的差异均有统计学意义(P<0.01);轻度组与对照组间血清Cys-C的差异无统计学意义(P>0.05);各组间血清BUN及Cr的差异无统计学意义(P>0.05)。结论:血清Cys-C能较早发现早产儿高胆红素血症的肾功能损害,可作为高胆红素血症早产儿肾功能损害早期诊断指标之一,且敏感性优于血清BUN和Cr。

Effect of neonatal hyperbilirubinemia on kidney function of premature infants

Objective:To explore the value of serum cystatin-C for evaluating the injury of kidney function of premature infants with hyperbilirubinemia.Methods:A total of 113 premature infants with hyperbilirubinemia were selected as study objects,then they were divided into mild group(25 infants),moderate group(15 infants),and severe group(11 infants),62 premature infants with normal bilirubin levels were selected as control group.The venous blood samples(2 ml) were obtained from 3 days to one week after birth in all the premature infants,immunoturbidimetry was used to detect the serum levels of cystatin-C,serum urea nitrogen and creatinine levels were measured,then the results were analyzed statistically on SPSS 11.0 software.Results:There was statistically significant difference in the serum level of cystatin-C between moderate group,severe group and control group(P<0.01);and there was statistically significant difference among mild group,moderate group,and severe group(P<0.01);there was no statistically significant difference between moderate group and control group(P>0.05);there was no statistically significant difference in the serum levels of urea nitrogen and creatinine among different groups.Conclusion:Serum cystatin-C can reveal kidney injury of premature infants with hyperbilirubinemia early,which can be used as a index to diagnose kidney injury in infants with hyperbilirubinemia early,and its sensitivity is superior to serum urea nitrogen and creatinine.