血清CA125在卵巢上皮性癌中的诊断、鉴别诊断意义及手术、术后CP方案化疗后的下降规律

目的:探讨血清CA125在卵巢上皮性癌中的诊断、鉴别诊断意义及手术、术后CP方案化疗后的下降规律。方法:回顾性分析171例卵巢上皮性癌新发病例的临床及病理资料,选取同期其他妇科疾病病例对比分析,并探讨其经手术、CP方案化疗后血清CA125的下降规律。结果:血清CA125在几种妇科疾病中均有不同程度的升高,卵巢上皮性癌血清CA125明显高于其他几种疾病。结论:血清CA125对卵巢上皮性癌具有重要的诊断及鉴别诊断意义,其在卵巢上皮性癌经手术、术后CP方案化疗后大约在(76±28)天相当于术后经0～6个疗程降至正常,故临床上术后常行6～8个疗程CP方案化疗。

Diagnostic and differential diagnostic significances of serum CA125 in epithelial ovarian cancer and the decline law of serum CA125 in epithelial ovarian cancer after surgery and postoperative chemotherapy with CP schedule

Objective:To explore the diagnostic and differential diagnostic significances of serum CA125 in epithelial ovarian cancer and the decline law of serum CA125 in epithelial ovarian cancer after surgery and postoperative chemotherapy with CP schedule. Methods:The clinical data and pathological data of 171 new cases with epithelial ovarian cancer were analyzed retrospectively,then the cases with other gynecological diseases during the same period were selected as control group;the decline law of serum CA125 after surgery and postoperative chemotherapy with CP schedule was discussed. Results:The levels of serum CA125 increased in several gynecological diseases in varying degrees.The level of serum CA125 in cases with epithelial ovarian cancer was significantly higher than those in cases with other several gynecological diseases. Conclusion:Serum CA125 has important diagnostic and differential diagnostic significances for epithelial ovarian cancer.At(76±28) days after surgery and postoperative chemotherapy with CP schedule,the level of serum CA125 decreases to normal level,which is equivalent to 0-6 courses of treatment,so usually 6-8 courses of treatment of postoperative chemotherapy with CP schedule are carried out in clinic.