418例新生儿窒息与高胆红素血症的关系分析

目的:探讨新生儿窒息对新生儿高胆红素血症(下称高胆)的影响。方法:对418例窒息新生儿高胆的发生率进行回顾性临床分析。分轻度窒息组和重度窒息组,同期住院无窒息新生儿为对照组。对有皮肤黄疸的新生儿应用经皮胆红素测定仪动态观察,结果接近高胆诊断标准时,测血清胆红素浓度及肝功能。结果:轻度窒息组(279例)、重度窒息组(139例)、无窒息组(4 827例)高胆发生率分别为17.20%、10.07%、59.29%,三组间比较,差异有统计学意义(χ2=315.792,P<0.01),轻度窒息组与重度窒息组高胆发生率低于无窒息组;轻度窒息组与无窒息组相比,差异有统计学意义(χ2=188.893,P<0.01),轻度窒息组高胆发生率低于无窒息组;重度窒息组与无窒息组比较,差异有统计学意义(χ2=132.277,P<0.01),重度窒息组高胆发生率低于无窒息组;轻度窒息组与重度窒息组比较,差异无统计学意义(χ2=3.193,P>0.05)。结论:轻度窒息、重度窒息新生儿高胆发生率均低于无窒息新生儿。

Analysis on the relationship between neonatal asphyxia and hyperbilirubinemia in 418 neonates

Objective:To explore the effect of neonatal asphyxia on neonatal hyperbilirubinemia. Methods:The incidences of hyperbilirubinemia in 418 neonates with asphyxia were analyzed retrospectively,then the neonates were divided into mild asphyxia group and severe asphyxia group,the neonates without asphyxia who hospitalized in the hospital during the same period were selected as control group.The neonates with skin jaundice were observed dynamically by transcutaneous bilirubin determinator,when the results approached the diagnostic criteria of hyperbilirubinemia,the concentration of serum bilirubin and liver function were detected. Results:The incidence of hyperbilirubinemia in mild asphyxia group(279 neonates),severe asphyxia group(139 neonates),and control group(4 827 neonates) was 17.20%,10.07%,and 59.29%,respectively,there was statistically significant difference in the incidence of hyperbilirubinemia among the three groups(χ2=315.792,P<0.01);the incidences of hyperbilirubinemia in mild asphyxia group and severe asphyxia group were statistically significantly lower than that in control group(χ2=188.893,P<0.01)(χ2=132.277,P<0.01);there was no statistically significant difference in the incidence of hyperbilirubinemia between mild asphyxia group and severe asphyxia group(χ2=3.193,P>0.05). Conclusion:The incidences of hyperbilirubinemia in neonates with mild asphyxia and severe asphyxia are statistically significantly lower than that in neonates without asphyxia.