奥硝唑治疗滴虫性阴道炎的疗效及细胞因子IL-2、IL-8和IL-13的变化

目的:研究奥硝唑治疗滴虫性阴道炎的疗效及其对治疗前后患者阴道分泌物中细胞因子IL-2、IL-8和IL-13的影响。方法:将滴虫性阴道炎患者按就诊顺序分为观察组和对照组各70例,观察组使用奥硝唑治疗,对照组使用甲硝唑治疗,评价治疗的效果并检测治疗前后阴道灌洗液中IL-2、IL-8和IL-13的变化。结果:服药7天后,观察组的治疗效果优于对照组,总有效率分别为94.28%和85.71%,差异有统计学意义(P<0.05)。两组患者治疗后阴道灌洗液中的IL-2、IL-8和IL-13均下降,观察组的下降值明显高于对照组。结论:奥硝唑治疗滴虫性阴道炎疗效显著,并能有效降低阴道分泌物中IL-2、IL-8和IL-13的水平,改善阴道的微环境,可在临床治疗广泛使用。

Clinical efficacy of ornidazole for treatment of trichomonas vaginitis and the changes of IL-2,IL-8,and IL-13

Objective:To study the clinical efficacy of ornidazole for treatment of trichomonas vaginitis and the effect on interleukin-2(IL-2),IL-8,and IL-13 in vaginal secretions before and after treatment.Methods:The patients with trichomonas vaginitis were divided into observation group and control group according to the sequence of on admission,70 patients in each group,the patients in observation group were treated with ornidazole and the patients in control group were treated with metronidazole;the curative effects in the two groups were evaluated,and the changes of IL-2,IL-8,and IL-13 levels in vaginal lavage fluid before and after treatment were detected.Results:The curative effect in observation group at seven days after treatment was superior to that in control group,the total effective rates in the two groups were 94.28% and 85.71%,respectively,there was statistically significant difference between the two groups(P<0.05).After treatment,the levels of IL-2,IL-8,and IL-13 in vaginal lavage fluid in the two groups decreased,the decreasing amplitude in observation group was significantly higher than that in control group.Conclusion:The curative effect of ornidazole for treatment of trichomonas vaginitis is dominant.Ornidazole can reduce the levels of IL-2,IL-8,and IL-13 in vaginal secretions effectively and improve vaginal microenvironment,which can be used for clinical treatment extensively.