微粉硅胶用于白芷提取物粉体改性及其促进元胡止痛分散片崩解的原理研究

目的 研究微粉硅胶用于白芷提取物粉体改性及其促进元胡止痛分散片崩解的原理.方法 采用混合与液相分散两种方法,微粉硅胶3％、5％、7％3种改性剂量对白芷提取物进行粉体改性,研究粉体改性前后在红外光谱、比表面积与孔隙度、接触角、差示扫描量热、扫描电镜的差异及其对元胡止痛分散片崩解时间的影响.结果 红外光谱显示液相分散法与混合法的改性方式相同,均属物理改性;改性后,粉体的比表面积与孔隙体积显著增加,接触角显著降低,热效应显著变化；当微粉硅胶用量达到5％时,两种方法均能改善元胡止痛分散片的崩解性能.结论 增强白芷提取物比表面积,增强吸水性、润湿性,分散提取物,降低黏性可能是微粉硅胶改性及促进分散片崩解的主要机制.

Research on micro-silica gel used for powder modification of Angelicae Dahuricae Radix extract and its mechanism of promoting disintegration of Yuanhu Zhitong Dispersible Tablets

Objective To study the principle of micro-silica gel used for the powder modification of Angelicae Dahuricae Radix(ADR) extract and the mechanism of micro-silica gel promoting the disintegration time of Yuanhu Zhitong Dispersible Tablets (YZDT). MethodsUsing mixing and liquid dispersion methods, micro-silica gel in three doses (3%, 5%, and 7%) was prepared for powder modification of ADR extract. The infrared (IR) spectrogram, specific surface area, porosity, contact angle, differential scanning calorimetry (DSC), and scanning electronic microscope (SEM) were compared before and after powder modification and the effects on YZDT disintegration time was also investigated. Results The IR spectrograms showed that mixing and liquid dispersion methods were all physical modification. After modification, the specific surface area and pore volume increased, contact angle decreased obviously, and heat effect changed dramatically. When 5% micro-silica gel was used, YZDT disintegrating properties could be improved by the both two methods. Conclusion The principal mechanism of micro-silica gel for the powder modification and the disintegration promotion of YZDT is mainly to increase the specific surface area, promote water absorption and wettability, increase the disintegration, reduce cohesion, and overcome stickiness