补肾益气胶囊治疗卵巢早衰临床效果观察 |
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引用本文: | 杨丽,赵苏萍,黄月娜,高丽,杨兰. 补肾益气胶囊治疗卵巢早衰临床效果观察[J]. 中国妇幼保健, 2012, 27(32): 5196-5199 |
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作者姓名: | 杨丽 赵苏萍 黄月娜 高丽 杨兰 |
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作者单位: | 1. 贵州省黔南民族医学高等专科学校 贵州 都匀558001 2. 贵州省黔南民族医学高等专科学校第二附属医院 |
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基金项目: | 贵州省中医药管理局重点资助项目〔黔中医2011078002〕 |
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摘 要: | 目的:观察补肾益气胶囊治疗卵巢早衰的临床疗效及安全性。方法:将41例卵巢早衰患者随机分治疗组21例采用补肾益气胶囊治疗,对照组20例采用口服倍美力治疗。两组均连续治疗3个疗程(3个月为1疗程),分别观察两组的临床疗效及治疗前后患者血清E2、FSH、LH、P、PRL水平及外周T淋巴细胞亚群的变化。结果:治疗组临床治愈8例,显效7例,有效4例,无效2例,有效率90.48%;对照组临床治愈4例,显效7例,有效3例,无效6例,总有效率70.00%,两组差异有统计学意义(P<0.05)。两组患者治疗前血清FSH、E2、LH、P、PRL含量比较差异无统计学意义(P>0.05);两组患者治疗后血清E2、P含量水平升高,而FSH、LH、PRL含量水平下降,与治疗前比较差异有统计学意义(P<0.01)。两组患者治疗前外周血T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+比值比较差异无统计学意义(P>0.05);治疗组治疗后CD3+、CD4+、CD4+/CD8+比值上升,CD8+含量下降,与对照组比较差异有统计学意义(P<0.01)。结论:补肾益气胶囊能明显改善卵巢早衰患者的临床症状,具有良好的治疗作用。
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关 键 词: | 卵巢早衰 补肾益气胶囊 雌激素 |
Observation of clinical efficacy of Bushenyeqi capsule on premature ovarian failure |
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Affiliation: | YANG Li,ZHAO Su-Ping,HUANG Yue-Na,et al.Qiannan Nationalities Medical College,Duyun 558001,Guizhou,China |
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Abstract: | Objective:To observe the clinical efficacy and safety of Bushenyeqi capsule on premature ovarian failure(POF). Methods:A total of 41 patients with POF were randomly divided into Bushenyeqi capsule group(21 patients) and control group(20 patients).The patients in Bushenyeqi capsule group took the capsule orally,3 capsules each time,3 times a day.6g for every day.The patients in control group took the premarin only,0.625mg each time,1 times a day.The courses of treatment for both groups were 9 months totally.Blood estradiol(E2),follicle-stimulating hormone generation(FSH),luteinizing hormone(LH),progesterone(P),prolactin(PRL) and level of T-lymphocyte in POF for the patients in both groups were measured before and after treatment.The NRS scoring was performed after treatment. Results:①Comparison of clinical efficacy for the patients in both groups: among the 21 cases of Bushenyeqi capsule group,there were 8 cases cured(38.09%),7 cases excellent(33.33%),4 cases effective(19.05%),and 2 non-effective(9.52%),with total effective rate of 90.48%.Among the 20 cases of control group,there were 4 cases cured(20.00%),7 cases excellent(35.00%),3 cases effective(15.00%),and 6 non-effective(30.00%),with total effective rate of 70.00.There was statistically significant on clinical efficacy between the two groups(P<0.05).② Comparison of the level of sex hormone for the patients in both groups before and after treatment: there was not statistically significant on the level of FSH,E2,LH,P,PRL in serum between the two groups before treatment(P>0.05).After nine months of treatment,there was significant change on the serum E2,P level of the patients in both groups.However,the levels of FSH,LH,PRL in serum decreased.There was statistically significant on the level of FSH,E2,LH,P,PRL in serum before and after treatment,respectively(P<0.01).③ Comparison of the level of T-lymphocyte for the patients in both groups before and after treatment: the level of CD3+,CD4+,CD8+,CD4+/CD8+in serum of the patients in Bushenyeqi capsule group significantly creased,but CD8+was decreased.There was statistically significant difference between the two groups(P<0.01). Conclusion:Bushenyeqi capsule has a good therapeutic action on premature ovarian failure.The therapeutic mechanism may be related to the raising of immune function. |
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Keywords: | Premature ovarian failure Bushenyeqi capsule Estradiol. |
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