Alzheimer病与帕金森综合征：附六例临床病理报告

目的 Ａｌｚｈｅｉｍｅｒ病（ＡＤ）临床多合并帕金森综合征。报道６例经尸检证实的ＡＤ临床及病理资料，旨在为ＡＤ合并锥体外系受损的病因探讨提供参考资料。 方法 回顾性分析６例ＡＤ及４例原发性帕金森病的临床及病理资料 结果 ６例ＡＤ中有３例临床合并帕金森综合征，其黑质、蓝斑均有不同性质及程度的损伤，２例系非特征性色素细胞脱失伴胶质细胞增生，１例为球形体色素变性。 结论 ＡＤ合并帕金森综合征者多有黑质、蓝

Cliulcal and pathological features of Parkinsonism in Alzheimer's disease

Objective Because patients with Alzheimer's disease often develop clinical manifestations of Parkinsonism, 6 cases of Alzheimer's disease (AD) confirmed by neuropathological examinations were reviewed in order to explain the extrapyramidal signs in AD. Methods Six cases of AD and 4 cases of Parkinson's desease were enrolled for the clinical and pathological study. Results Coexistent Parkinsonism was present in 3 cases of AD. Pathological examination revealed nonspecific degeneration, including pigmented neuronal loss and gliosis in substantia nigra and locus ceruleus in 2 cases and spheroid pigmentary degeneration in one case. Conclusion In cases of AD with clinical manifestations of Parkinsonism , pathological lesions were found in substantia nigra and locus ceruleus ,but they were heterogenous in nature.