| 原发性高血压合并脑卒中患者血管紧张素Ⅰ转换酶基因多态性分析 |
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| 引用本文： | 赖玉琼,熊华峰,胡晖,崔金环,刘晓松.原发性高血压合并脑卒中患者血管紧张素Ⅰ转换酶基因多态性分析[J].高血压杂志,1999(2). |
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| 作者姓名： | 赖玉琼 熊华峰 胡晖 崔金环 刘晓松 |
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| 作者单位： | 广东省佛山市第一人民医院心内科 |
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| 摘 要： | 目的探讨血管紧张素转换酶（ＡＣＥ）基因第１６内含子的插入／缺失（Ｉ／Ｄ）多态性与原发性高血压合并脑卒中的关系。方法应用聚合酶链反应（ＰＣＲ）扩增技术检测５０例原发性高血压合并脑卒中患者（脑卒中组），７８例原发性高血压和１５５例健康对照组。结果脑卒中组Ｉ型（５２％）显著高于对照组（３４％）（Ｐ＝０．０２５）。ＤＤ型（８％）远低于对照组（２０％）（Ｐ＝０．０４９）。而ＩＤ型则无明显差异。７８例原发性高血压组与对照组相比无显著差异。Ｉ等位基因频率在脑卒中组（７２％）显著高于对照组（５７％）（Ｐ＝０．００８），非脑卒中组与对照组相近。结论ＡＣＥ基因的插入／缺失多态性与原发性高血压合并脑卒中发病相关，Ｉ等位基因及Ｉ基因型可能为原发性高血压合并脑卒中的独立危险因素之一。
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| 关 键 词： | 血管紧张素转换酶 基因多态性 脑血管意外 高血压 |
Relationship of Insertion/deletion Angiotensin Converting Enzyme Gene Polymorphism in
Hypertensive Complicated with Stroke |
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| LAI Yuqiong,XIONG Huafeng,HU Hui,CUI
Jinhuan,LIU Xiaosong\=.Relationship of Insertion/deletion Angiotensin Converting Enzyme Gene Polymorphism in
Hypertensive Complicated with Stroke[J].Chinese Journal of Hypertension,1999(2). |
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| Authors: | LAI Yuqiong XIONG Huafeng HU Hui CUI
Jinhuan LIU Xiaosong\= |
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| Abstract: | Aim \ To investigate the ACE gene polymorphism in occurence of stroke in Chinese
population.\ Methods \ Genotyping with polymerase chain reaction(PCR) was performed in 50
cases of essential hypertension complicated with stroke,78 cases of essential hypertension
without stroke and 155 healthy subjects as controls.\ Results \ The II genotype was shown to
be more common in essential hypertensive patients with stroke(26/50 vs healthy subjects
53/155,P=0.025),whereas, The designatve DD genetype is lower than control group.\
Conclusion \ The insertion polymorphism in the angiotensin converting enzyme gene might be
a independent risk factor in stroke patients. |
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| Keywords: | angiotensin converting enzyme \ gene polymorphism \ essential hypertenion \ cerebrovascular disordors |
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