慢性充血性心力衰竭患者血清可溶性细胞间粘附分子-1的变化及与C-反应蛋白的相关性分析

目的了解慢性充血性心力衰竭(心衰)患者血清可溶性细胞间粘附分子-1(sICAM-1)的变化及与C-反应蛋白(CRP)的相关性.方法测定60例心衰患者和20例健康人的血清sICAM-1及CRP水平.比较分析心衰患者及不同程度心衰患者之间sICAM-1、CRP水平的变化,以及sICAM-1与CRP的相关性.结果心衰患者血清sICAM-1及CRP水平明显高于健康对照组(P＜0.01),二者均随心衰程度加重而增高,呈高度正相关(r=0.68,P＜0.01).不同程度心衰患者之间血清sICAM-1及CRP水平差异有显著性(P＜0.05).结论心衰患者存在着免疫激活和心肌炎症反应,心衰程度愈重,炎症反应愈明显.

RELATIONSHIP OF SERUM Sicam-1 AND CRP IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE

Objective To study the changes and relationship of serum soluble ICAM- 1 (sICAM- 1) and C- reactive protein (CRP) in patients with chronic congestive heart failure (CHF). Methods Serum sICAM - 1 and CRP were measured in 60 cases with CHF and 20 healthy controls. The changes and relationship of serum sICAM - 1 and CRP were analysed in patients with CHF, and were compared among patients with CHF in different severity. Results The levels of serum sICAM - 1 and CRP in patients with CHF were significantly higher than those of controls( P < 0. 01). Both were significantly correlatived( r = 0. 68, P< 0. 01). There were significant difference in serum sICAM - 1 andCRP among patients with CHF in different severity (P<0.05). Conclusion The inflammatory and immunological activation occurr in Patients with CHF, the more severe CHF is, the more notable inflammation will be.