Association of sleep disturbances with obesity,insulin resistance and the metabolic syndrome |
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| Institution: | 1. Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA;2. Division of General Academic Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA;1. IMPACT SRC, School of Medicine, Deakin University, Geelong, Australia;2. Institute for Breathing and Sleep, Austin Health, Melbourne, Australia;3. Department of Psychiatry, The University of Melbourne, Parkville, Australia;4. School of Psychology, Counselling & Psychotherapy, Cairnmillar Institute, Camberwell, Australia;5. NorthWest Academic Centre, Department of Medicine, The University of Melbourne, St Albans, Australia;6. Orygen Research Centre, Parkville, Australia;7. Florey Institute for Neuroscience and Mental Health Parkville Australia;1. University Grenoble Alpes, HP2, Inserm 1042, Grenoble F-38042, France;2. Physiology Sleep and Exercise Clinic, Thorax and Vessel division, Grenoble Alpes hospital, Grenoble 38043, France;3. Pulmonary Physiology Laboratory, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States;1. Division of Pulmonary, Critical Care, and Sleep Medicine, UC San Diego Department of Medicine, La Jolla, CA, United States;2. Division of Endocrinology, UC San Diego Department of Medicine, La Jolla, CA, United States;1. Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, United States;2. Département de Pneumologie, Centre de Recherche Clinique, CHU d''Angers, Université Bretagne Loire, UNIV Angers, INSERM UMR 1063, Angers, France |
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| Abstract: | Insufficient sleep, which has become endemic in recent years, has been variably associated with increased risk of obesity, disorders of glucose and insulin homeostasis, and the metabolic syndrome; to a lesser degree, so has excessive sleep. This review summarizes recent epidemiological and pathophysiological evidence linking sleep disturbances (primarily abnormalities of sleep duration) with obesity, insulin resistance, type 2 diabetes and the metabolic syndrome in children and adults. |
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