Functional regulation of large conductance Ca2+-activated K+ channels in vascular diseases |
| |
| Affiliation: | 1. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;2. Division of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno, Italy;3. ANMCO Research Center, Florence, Italy;4. Department of Cardiology, Santa Maria degli Angeli Hospital, Pordenone, Italy;5. Therapeutic Science and Strategy Unit (TSSU), IQVIA, Milan, Italy;6. Department of Cardiovascular Research, IRCCS-Istituto di Ricerche Famacologiche Mario Negri, Milan, Italy;7. Division of Cardiology, Ospedale Valdichiana Santa Margherita, Cortona, Italy;8. Maria Cecilia Hospital, GVM Care & Research, Ettore Sansavini Health Science Foundation, Cotignola, Italy;1. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore;2. Duke-NUS Medical School, Singapore;3. KK Women''s and Children''s Hospital, Singapore;4. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore;5. Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;6. Singapore Institute for Clinical Sciences, Growth, Development & Metabolism, Singapore;1. Department of Nutrition -Dietetics, Harokopio University, 70 El. Venizelou Street, 17671 Athens, Greece;2. Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis, 15771 Athens, Greece;1. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;2. Universiti Teknologi MARA, Kuala Lumpur, Malaysia;1. Department of Medical Physiology, Chiba University, Graduate School of Medicine, Chiba 260-8670, Japan;2. Department of Clinical Cell Biology and Medicine, Chiba University, Graduate School of Medicine, Chiba 260-8670, Japan;3. Division of Endocrinology, Department of Medicine, Columbia University, New York 10032, USA;4. Center for Preventive Medical Sciences, Chiba University, Chiba 263-8522, Japan |
| |
| Abstract: | The large conductance Ca2+-activated potassium channels, the BK channels, is widely expressed in various tissues and activated in a Ca2+- and voltage-dependent manner. The activation of BK channels hyperpolarizes vascular smooth muscle cell membrane potential, resulting in vasodilation. Under pathophysiological conditions, such as diabetes mellitus and hypertension, impaired BK channel function exacerbates vascular vasodilation and leads to organ ischemia. The vascular BK channel is composed of 4 pore-forming subunits, BK-α together with 4 auxiliary subunits: β1 subunits (BK-β1) or γ1 subunits (BK-γ1). Recent studies have shown that down-regulation of the BK β1 subunit in diabetes mellitus induced vascular dysfunction; however, the molecular mechanism of these vascular diseases is not well understood. In this review, we summarize the potential mechanisms regarding BK channelopathy and the potential therapeutic targets of BK channels for vascular diseases. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
