Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis |
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| Authors: | Shen Xin Shen Guo-miao Wu Jie Gui Xiao-hong Li Xia Mei Jian DeRiemer Kathryn Gao Qian |
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| Affiliation: | Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 20032, China. |
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| Abstract: | embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis. |
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