新生儿脑18F-FDG PET显像初步研究

目的 观察部分新生儿肺炎患儿和早产儿的脑^18F-脱氧葡萄糖（FDG）PET显像图,从代谢角度分析其脑功能.方法 对9例新生儿肺炎患儿及7例早产儿行脑^18F-FDG PET检查.结果 新生儿正常脑^18F-FDG PET影像与成人及儿童明显不同,整个脑的结构不清晰,其葡萄糖代谢活性区主要集中在丘脑、小脑、感觉运动皮质、基底节等脑组织,其中丘脑摄取^18F-FDG最多,大脑皮质摄取^18F-FDG的量较低.分别用1、2、3 min的透射采集作衰减校正,所得图像质量无明显差异.结论 脑^18F-FDG PET显像可作为研究新生儿脑功能代谢行之有效的方法之一.对新生儿行脑^18F-FDGPET显像应尽量减少透射采集时间.

Preliminary investigation of brain 18F-FDG PET imaging in neonate

Objective To study brain ~(18)F-fluorodeoxyglucose(FDG)PET imaging and to under- stand its metabolic function in neonate with pneumonia and premature infants.Methods Nine neonate with pneumonia and seven premature infants were examined with routine ~(18)F-FDG PET brain scan.Results The brain ~(18)F-FDG PET image of neonate was significantly different from that of adult and child.The structure of whole brain was not clearly demarcated.The active glucose metabolic areas were in thalamus,cerebellum, sensorimotor cortex and basal ganglia.The ~(18)F-FDG uptake was most in thalamus,while least in cerebral cortex.The image quality showed no significant difference among 1,2 and 3 min transmission scan for at- tenuation correction.Conclusions ~(18)F-FDG PET brain imaging may be one of effective methods to study cerebral function and metabolism in neonate.But the CT transmission time should reduce to be the shortest.