双氯芬酸钠插层镁铝水滑石的制备及其性能研究

目的研究双氯芬酸钠插层镁铝水滑石的制备及其性能。方法先采用羟丙基-β-环糊精对双氯芬酸钠进行增溶,再采用共沉淀法将双氯芬酸钠插入到镁铝水滑石层间,制备了含有少量羟丙基-β-环糊精的双氯芬酸钠插层镁铝水滑石。采用X射线衍射、红外光谱、热重-差热和元素分析对材料进行表征。结果确定双氯芬酸钠插层镁铝水滑石已合成,化学式为Mg0.69Al0.31(OH)2(双氯芬酸钠)0.30.2.0H2O。结论与双氯芬酸钠相比,双氯芬酸钠插层镁铝水滑石的缓释性能有了大幅度地提高,并且体外释放符合Bhaskar模型。

Preparation of diclofenac sodium-Mg-Al-hydrotalcite and its properties

Objective To study the preparation of diclofenac sodium-Mg-Al-hydrotalcite and its properties.Methods Hydroxypropyl-β-cyclodextrin was applied to increasing the solubility of diclofenac sodium.Then diclofenac sodium was intercalated into the Mg-Al-hydrotalcite to form an organic and inorganic complex material by the method of co-precipitation.The complex materials were characterized by X-ray diffraction(XRD),infrared spectroscopy(IR),thermogravimetric-differential thermal analysis(TG-DTA),and elemental analysis.Results The diclofenac sodium-Mg-Al-hydrotalcite was formed and its chemical formula was Mg0.69Al0.31(OH)2(diclofenac sodium)0.30.2.0H2O.Conclusion Comparing with diclofenac sodium,sustained release of diclofenac sodium-Mg-Al-hydrotalcite is improved and the release profile in vitro fits Bhaskar distribution well.