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泪腺良性淋巴上皮病变临床表现及诊断思路的研究
引用本文:李静,葛心,马建民,史季桐,崔忆辛. 泪腺良性淋巴上皮病变临床表现及诊断思路的研究[J]. 临床眼科杂志, 2012, 20(3): 193-195
作者姓名:李静  葛心  马建民  史季桐  崔忆辛
作者单位:北京同仁眼科中心 首都医科大学附属北京同仁医院 北京市眼科学与视觉科学重点实验室,北京,100730
基金项目:国家自然科学基金,北京市卫生系统高层次卫生技术人才培养计划课题
摘    要:目的探讨泪腺良性淋巴上皮病变(BLEL)的临床特点和诊断方法。方法回顾性系列病例研究。收集2010年8月至2011年10月间经病理证实的泪腺BLEL患者资料16例,分析和总结其临床特点、影像学表现及实验室检查结果。结果 16例患者中男:女=1:7;年龄为36~63岁,其中以41~50岁为多;单眼发病:双眼发病=1:7;上眼睑无痛性非充血性持续肿胀为其主要临床表现。眼眶MRI成像扫描显示,16例患者病变均累及眼睑和泪腺组织,受累泪腺明显肿大,T1WI和T2WI均呈等信号,增强扫描可见明显均匀强化,另外,3例患者眼外肌受累,1例颞肌受累,1例额神经受累;实验室检查仅1例患者丙肝抗体阳性,余未见异常。结论眼睑肿胀是BLEL的典型症状,受累泪腺以双侧居多;MRI成像检查在诊断BLEL中具有重要价值,但确诊该病需要有病理组织学检查结果的支持。

关 键 词:良性淋巴上皮病变  临床表现  核磁共振成像

Clinical manifestations and dlagnostic methods for benign lymphoepithelial lesion of lacrimal gland
LI Jing , GE Xin , MA Jian-min , SHI Ji-tong , CUI Yi-xin. Clinical manifestations and dlagnostic methods for benign lymphoepithelial lesion of lacrimal gland[J]. Journal of Clinical Ophthalmology, 2012, 20(3): 193-195
Authors:LI Jing    GE Xin    MA Jian-min    SHI Ji-tong    CUI Yi-xin
Affiliation:.Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology & Vision Science Key Lab,Beijing 100730,China
Abstract:Objective To analyze the clinical features and diagnostic methods for benign lymphoepithelial lesion(BLEL) of lacrimal gland.Methods 16 consecutive cases with benign lymphoepithelial lesion confirmed by histopathologic examination were retrospsctively reviewed,and the clinical features,imaging findings and laboratory tests was analyzed.Results In all 16 cases,the ratio of male to female was 1:7;age range was from 36 to 63 years old,in which most of them aged between 41 and 50;the ratio of unilateral eye to bilateral eyes was 1:7,painless uncongestive continuous swelling of the upper eyelid(s) was the main clinical manifestation.Orbital magnetic resonance imaging(MRI) showed that all cases involved both eyelid(s) and lacrimal gland that were enlarged obviously with equal signal in T1WI and T2WI with obvious enhancement on contrast MRI.Extraocular muscle was involved in 3 cases,temporalis was involved in 1 case and frontal nerve was involved in 1 case;there were no other abnormal foundings except one patient with positive hepatitis C antibody in laboratory tests.Conclusion Eyelid swelling is the typical symptom of BLEL.Most of cases involve bilateral lacrimal gland.Although MRI has high value for diagnosing BLEL,confirmed diagnosis mainly depends on pathological examination.
Keywords:Benign lymphoepithelial lesion  Clinical manifestation  Magnetic resonance imaging
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