| 子宫内膜HOXA10及白血病抑制因子mRNA表达水平与体外受精-胚胎移植妊娠结局的关系 |
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| 引用本文： | 马彩辉,张清学,李予,王文军,麦美琪,杨冬梓,陈向红.子宫内膜HOXA10及白血病抑制因子mRNA表达水平与体外受精-胚胎移植妊娠结局的关系[J].临床医学,2012,32(4):1-4. |
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| 作者姓名： | 马彩辉 张清学 李予 王文军 麦美琪 杨冬梓 陈向红 |
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| 作者单位： | 1. 解放军第一七四医院生殖医学中心,福建厦门,361000
2. 中山大学附属第二医院生殖医学中心 |
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| 摘 要： | 目的探讨子宫内膜HOXA10、白血病抑制因子(LIF)mRNA表达水平与体外受精-胚胎移植(IVF/ICSI-ET)妊娠结局的关系。方法前瞻性收集了行IVF/ICSI-ET者59例,其中21例临床妊娠者作为妊娠组,38例未妊娠者作为非妊娠组,于前1个月经周期的黄体中期取内膜,应用RT-PCR技术检测子宫内膜HOXA10 mRNA和LIF mRNA的表达水平。结果妊娠组与未妊娠组黄体中期子宫内膜LIF mRNA水平分别为1.12±0.32和0.94±0.14,差异有统计学意义(P<0.05);妊娠组与未妊娠组分泌中期子宫内膜HOXA10 mRNA水平分别为0.68±0.12和0.62±0.07,差异有统计学意义(P<0.05)。结论分泌中期子宫内膜HOXA10 mRNA和LIF mRNA表达水平与体外受精-胚胎移植妊娠结局有相关性。
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| 关 键 词： | HOXA10 白血病抑制因子 体外受精-胚胎移植 子宫内膜容受性 |
Relationship between expression of endometrial HOXA10, LIF mRNA and the outcome of IVF/ICSI-ET |
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| MA Cai-hui
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ZHANG Qing-xue
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LI Yu
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WANG Wen-jun
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MAI Mei-qi
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YANG Dong-zi
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CHEN Xiang-hong.Relationship between expression of endometrial HOXA10, LIF mRNA and the outcome of IVF/ICSI-ET[J].Clinical Medicine,2012,32(4):1-4. |
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| Authors: | MA Cai-hui ZHANG Qing-xue LI Yu WANG Wen-jun MAI Mei-qi YANG Dong-zi CHEN Xiang-hong |
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| Institution: | 1) Center of Reproductive Medicine,NO.174 Hospital of People’s Liberation Army,Xiamen 361000,China;2) Center of Reproductive Medicine,the Second Affiliated Hospital of Sun Yat-sen University |
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| Abstract: | Objective To evaluate the relationship between expression of endometrial HOXA-10,LIF mRNA and the outcome of IVF/ICSI-ET.Methods Fifty-nine women underwent IVF/ICSI-ET were collected,21 women who successfully became pregnant were selected as pregnant group,38 women who failed to be pregnant were selected as non-pregnant group.RT-PCR was performed to detect the expression of HOXA10 mRNA and LIF mRNA in endometrial samples.Results LIF mRNA in the endometria was 1.12±0.32 in the pregnant group and 0.94±0.14 in the non-pregnant group.The difference between the two groups was significant（P〈0.05）;HOXA10 mRNA in the endometria was 0.68±0.12 in the pregnant group and 0.62±0.07 in the non-pregnant group.The difference between the two groups was significant（P〈0.05）.Conclusion The expression of HOXA10 mRNA and LIF mRNA in endometrium are correlated with the outcome of IVF/ICSI-ET. |
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| Keywords: | Leukemia inhibitory factor HOXA10 IVF-ET Pregnancy |
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