| 喹诺酮类抗菌药的耐药性机制及研究进展 |
| |
| 引用本文： | 宋莹,江振洲,张陆勇.喹诺酮类抗菌药的耐药性机制及研究进展[J].现代药物与临床,2012,35(3):199-203. |
| |
| 作者姓名： | 宋莹 江振洲 张陆勇 |
| |
| 作者单位： | 1.中国药科大学，江苏 南京 210009 2.江苏省新药筛选中心，江苏 南京 210009 |
| |
| 基金项目： | 江苏省省级科技创新与成果转化专项引导资金项目（BE2008672） |
| |
| 摘 要： | 植物中的活性成分是植物药发挥疗效的物质基础,植物活性成分研究是阐释植物药的生物活性、临床疗效和毒性的必要手段,也是新药发现和创制的可行途径,更是中药药效物质基础研究、
|
| 关 键 词： | 活性成分 植物药 图书出版 生物活性 规划项目 成分研究 可行途径 中药药效物质 植物拉丁学名 临床疗效 |
| 收稿时间： | 2012/3/20 0:00:00 |
Advances in studies on quinolone resistance and its mechanisms |
| |
| SONG Ying,JIANG Zhen-zhou,ZHANG Lu-yong.Advances in studies on quinolone resistance and its mechanisms[J].Drugs & Clinic,2012,35(3):199-203. |
| |
| Authors: | SONG Ying JIANG Zhen-zhou ZHANG Lu-yong |
| |
| Institution: | 1.China Pharmaceutical University, Nanjing 210009, China 2.Jiangsu Center for Drug Screening, Nanjing 210009, China |
| |
| Abstract: | Quinolones have potential and broad antimicrobial activity on gram-positive and -negative bacteria in clinic, respectively. They could interfere the duplication of bacteria by blocking the physiologic function of DNA gyrase and DNA topoisomerase IV. So quinolones have been used worldwide against a variety of infections. As a result of their frequent use, bacterial resistance to quinolones has gradually developed and limited their therapeutic efficacy in infections. This article reviews the antibacterial and resistance mechanisms of quinolone based on the recent research advances. |
| |
| Keywords: | quinolones drug resistance mechanisms of resistance |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
