| 多囊卵巢综合征胰岛素抵抗新进展 |
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| 引用本文： | 沈文娟,匡洪影,张跃辉,吴效科,侯丽辉.多囊卵巢综合征胰岛素抵抗新进展[J].国外医学：妇产科学分册,2011(5):407-410,414. |
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| 作者姓名： | 沈文娟 匡洪影 张跃辉 吴效科 侯丽辉 |
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| 作者单位： | 黑龙江中医药大学附属第一医院妇产科; |
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| 基金项目： | 国家中医药管理局2008中医药行业专项(200807021); 科技部国家“十一五”科技支撑计划(2007BAI20B015); 黑龙江省杰出青年基金(JC200804) |
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| 摘 要： | 多囊卵巢综合征（PCOS）是一种常见的影响育龄期女性生殖和内分泌功能的特殊疾病,其临床表现异质性,以慢性无排卵、卵巢多囊样改变、高雄激素血症为主要临床表现。胰岛素抵抗是其发生、发展的重要病理生理机制之一,也是导致高雄激素血症和卵巢功能改变的重要原因。近年来,PCOS患者胰岛素抵抗的分子机制得到深入研究,为临床治疗提供了理论依据。综述PCOS胰岛素抵抗的分子机制研究和药物治疗进展。
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| 关 键 词： | 多囊卵巢综合征 胰岛素抗药性 高胰岛素血症 葡萄糖钳制技术 二甲双胍 |
Molecular Mechanism and Management in Insulin Resistance in Polycystic Ovary Syndrome |
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| SHEN Wen-juan,KUANG Hong-ying,ZHANG Yue-hui,WU Xiao-ke,HOU Li-hui.Molecular Mechanism and Management in Insulin Resistance in Polycystic Ovary Syndrome[J].Foreign Medical Sciences(Obstet Gynecol Fascicle),2011(5):407-410,414. |
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| Authors: | SHEN Wen-juan KUANG Hong-ying ZHANG Yue-hui WU Xiao-ke HOU Li-hui |
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| Institution: | SHEN Wen-juan,KUANG Hong-ying,ZHANG Yue-hui,WU Xiao-ke,HOU Li-hui. Department of Gynecology and Obstetrics,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China |
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| Abstract: | Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorder with a variety of clinical manifestations among women of reproductive age. Its features include chronic anovulation,multicystic morphology of ovaries,hyperandrogenism. In recent years,insulin resistance(IR)has been regarded as one of the mechanisms of the development of PCOS,and is also associated with the hyperandrogenemia and dysfunction of ovaries. Many researches have been done on the molecular mechanism of IR in PCOS,which migh... |
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| Keywords: | Polycystic ovary syndrome Insulin resistance Hyperinsulinism Glucose clamp technique Metformin |
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