Platelet-derived growth factor signaling in human malignancies |
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| Authors: | Liu Kun-Wei Hu Bo Cheng Shi-Yuan |
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| Affiliation: | Kun-Wei Liu1,2*,Bo Hu1,3 and Shi-Yuan Cheng1,2 1University of Pittsburgh Cancer Institute,Departments of 2Pathology and 3Medicine,University of Pittsburgh School of Medicine,Pittsburgh,PA15213,USA. |
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| Abstract: | Platelet-derived growth factors(PDGFs) and their receptors were identified and purified decades ago.PDGFs are important during normal development and in human cancers.In particular,autocrine PDGF signaling has been implicated in various types of malignancies such as gliomas and leukemia.In contrast,paracrine signaling was found in cancers that originate from epithelial cells,where it may be involved in stromal cell recruitment,metastasis,and epithelial-mesenchymal transition.This editorial briefly discusses... |
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| Keywords: | Platelet-derived growth factor cancer tumor progression drug resistance |
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