| 晚期非小细胞肺癌患者使用EGFR-TKI治疗后长期生存的研究 |
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| 引用本文： | 管慧,李龙芸,王孟昭,王树兰,韩如冰,钟巍,冉然,周京伟,郑直.晚期非小细胞肺癌患者使用EGFR-TKI治疗后长期生存的研究[J].癌症进展,2011,0(5):561-568. |
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| 作者姓名： | 管慧 李龙芸 王孟昭 王树兰 韩如冰 钟巍 冉然 周京伟 郑直 |
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| 作者单位： | 中国医学科学院北京协和医学院北京协和医院呼吸科,北京,100730;中国医学科学院基础医学研究所,北京,100005 |
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| 摘 要： | 目的 探索应用表皮生长因子受体酪氨酸激酶抑制剂( EGFR-TKI)治疗晚期非小细胞肺癌(NSCLC)患者长期生存的影响因素,并研究长期生存者与EGFR突变关系.方法回顾性分析2002年12月至2007年6月在北京协和医院进行EGFR-TKI治疗的292例晚期NSCLC,并收集长期生存(定义为使用吉非替尼或厄洛替尼治疗...
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| 关 键 词： | 非小细胞肺癌 表皮生长因子受体 靶向治疗 |
Preliminary Study of long term survival of advanced non-small cell lung cancer patients treated with EGFR-TKI |
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| Guan Hui Li Longyun Wang Mengzhao Wang Shulan Han Rubing Zhong Wei Ran Ran Zheng Zhi.Preliminary Study of long term survival of advanced non-small cell lung cancer patients treated with EGFR-TKI[J].Oncology Progress,2011,0(5):561-568. |
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| Authors: | Guan Hui Li Longyun Wang Mengzhao Wang Shulan Han Rubing Zhong Wei Ran Ran Zheng Zhi |
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| Institution: | Guan Hui1 Li Longyun1 Wang Mengzhao1 Wang Shulan1 Han Rubing1 Zhong Wei1 Ran Ran1 Zheng Zhi2 1 Department of Respiratory Diseases,PUMCH,PUMC & CAMS,Beijing 100730,China 2 Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100005,China |
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| Abstract: | Objective To investigate the impact of epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI)as well as EGFR mutaionl status on long term survival of advanced non-small cell lung cancer(NSCLC)patients.Methods We retrospectively analyzed the clinical information of 292 advanced NSCLC patients who underwent EGFR-TKI therapy in Peking Union Medical College Hospital from December 2002 to June 2007.EGFR mutation data were collected and analyzed whenever available EGFR mutations in a subset of long ... |
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| Keywords: | non-small cell lung cancer epidermal growth factor receptor targeted therapy |
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